Schneider J, Moragues D, Martínez N, Romero H, Jimenez E, Pontón J
Departmento de Especialidades Médico-Quirúrgicas, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Vizcaya, Spain.
Br J Cancer. 1998 Mar;77(6):1015-20. doi: 10.1038/bjc.1998.167.
Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and immunohistochemistry. We have subsequently used one of them, PA10OF, to test by means of immunohistochemistry a series of 37 human ovarian carcinomas. Out of 37 tumours, 25 (67.6%) expressed the antigen recognized by PA1OF. The reactivity, however, was concentrated on the subgroup of particularly aggressive, invasive carcinomas in advanced stages of the disease (19 out of 24 positive), whereas the antigen was expressed significantly less (P=0.0007) in the subgroup of much less aggressive stage I tumours of low malignant potential, also called borderline carcinomas (2 out of 13 positive). This cross-reactivity between C. albicans and ovarian carcinoma seems to be attributable to a common antigenic determinant related to tumour aggressiveness.
摘要 据报道，抗白色念珠菌抗原决定簇的抗体可与人肿瘤细胞发生交叉反应。我们发现，我们实验室研制的两种针对白色念珠菌抗原决定簇的单克隆抗体C6和PA1OF，在蛋白质印迹法和免疫组织化学中与人卵巢癌发生交叉反应。随后，我们使用其中一种抗体PA1OF，通过免疫组织化学方法检测了37例人卵巢癌。在37个肿瘤中，25个（67.6%）表达了PA1OF识别的抗原。然而，反应性集中在疾病晚期特别侵袭性、浸润性癌的亚组中（24个阳性中有19个），而在侵袭性小得多的低恶性潜能I期肿瘤亚组（也称为交界性癌，13个阳性中有2个）中，该抗原的表达明显较少（P=0.0007）。白色念珠菌与卵巢癌之间的这种交叉反应似乎归因于与肿瘤侵袭性相关的共同抗原决定簇。
