Emödy L, Pál T, Safonova N V, Kuch B, Golutva N K
Acta Microbiol Acad Sci Hung. 1980;27(4):333-42.
Haemolytic Escherichia coli, including human intestinal and extraintestinal as well as porcine enterotoxigenic and oedema disease isolates, and Proteus morganii strains were studied for their virulence. Hly+ wild type strains and Hly+ transconjugants were more virulent than Hly- derivatives as shown in mice and chick embryos. This enhanced virulence seems to be connected with the ability of diffusible alpha-haemolysin production because clones producing only non-diffusible, beta-haemolysin behaved as non-haemolytic ones. Haemorrhagic lung symptoms and haemoglobinuria were frequently observed after parenteral challenge of mice with alpha-haemolytic clones. Though the Hly- clone exhibited a high resistance against blood clearance, the number of circulating bacteria was significantly higher in the case of alpha-haemolytic clone. A causal connection between this phenomenon and the leukocidin activity of alpha-haemolysin is suggested.
对包括人肠道和肠道外分离株以及猪产肠毒素和水肿病分离株在内的溶血性大肠杆菌和摩根氏变形杆菌菌株进行了毒力研究。如在小鼠和鸡胚中所示，Hly+野生型菌株和Hly+转接合子比Hly-衍生物的毒力更强。这种增强的毒力似乎与可扩散的α-溶血素产生能力有关，因为仅产生不可扩散的β-溶血素的克隆表现得如同非溶血克隆。用α-溶血克隆对小鼠进行肠胃外攻击后，经常观察到出血性肺部症状和血红蛋白尿。尽管Hly-克隆对血液清除表现出高抗性，但在α-溶血克隆的情况下，循环细菌数量明显更高。提示了这种现象与α-溶血素的杀白细胞活性之间的因果关系。
