Berard C W, Greene M H, Jaffe E S, Magrath I, Ziegler J
Ann Intern Med. 1981 Feb;94(2):218-35. doi: 10.7326/0003-4819-94-2-218.
Epidemiologic studies show that non-Hodgkin's lymphomas tend to develop after prolonged antigenic stimulation, after loss of normal regulation of lymphoid proliferation, or especially after both processes. Study of these tumors in vitro has greatly increased understanding of their pathophysiology and has provided a conceptual framework for their morphologic diversity. Lymphomas are now understood to be expanded clones of their normal counterparts. The anatomic location, phenotypic characteristics, proliferative capacity, and functional capabilities of the neoplasm often reflect those of the equivalent normal cells. If neoplastic transformation can occur at any stage of lymphoid differentiation, then it is theoretically possible that neoplastic lymphocytes may respond, or could be induced, to normal regulatory influences. Further study of selective cytotoxicity may reveal exploitable differences among lymphocytic subpopulations and permit more rational choices of therapy. Of major aid to future clinical trials should be the recent consensus on nomenclature by an international panel of experts.
流行病学研究表明，非霍奇金淋巴瘤往往在长期抗原刺激后、淋巴增殖正常调节丧失后，或特别是在这两个过程之后发生。对这些肿瘤的体外研究极大地增进了对其病理生理学的理解，并为其形态学多样性提供了一个概念框架。淋巴瘤现在被认为是其正常对应物的扩增克隆。肿瘤的解剖位置、表型特征、增殖能力和功能能力通常反映了相应正常细胞的特征。如果肿瘤转化可以发生在淋巴分化的任何阶段，那么从理论上讲，肿瘤淋巴细胞可能对正常调节影响作出反应，或者可以被诱导作出反应。对选择性细胞毒性的进一步研究可能揭示淋巴细胞亚群之间可利用的差异，并允许更合理地选择治疗方法。国际专家小组最近就命名达成的共识将对未来的临床试验有很大帮助。
