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麻风分枝杆菌中物种特异性脂质抗原的证据。

Evidence for species-specific lipid antigens in Mycobacterium leprae.

作者信息

Brennan P J, Barrow W W

出版信息

Int J Lepr Other Mycobact Dis. 1980 Dec;48(4):382-7.

PMID:7009448
Abstract

A partially purified lipid fraction from Mycobacterium leprae yielded distinct lines of precipitation with antisera from two lepromatus patients and from an infected armadillo. There was no reaction to the sera from patients with tuberculosis or a M. avium infection or to the serum from a normal armadillo. The activity in the lipid fraction was unaffected by mild alkali, and upon hydrolysis the fraction yielded 6-deoxyhexoses. This information suggests that the lipid antigens of M. leprae may be species specific and related to the A, B, C or G mycosides.

摘要

从麻风分枝杆菌中提取的部分纯化脂质组分,与两名瘤型麻风患者及一只感染犰狳的抗血清产生了明显的沉淀线。与肺结核患者、鸟分枝杆菌感染患者的血清以及正常犰狳的血清均无反应。脂质组分中的活性不受弱碱影响,水解后该组分产生6 - 脱氧己糖。这些信息表明,麻风分枝杆菌的脂质抗原可能具有种属特异性,且与A、B、C或G霉菌糖苷相关。

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