Ogurtsov R P, Kazakov V K, Zubzhitskiĭ Iu N
Biull Eksp Biol Med. 1981 Feb;91(2):193-5.
Ability of homologous antistreptococcal sera obtained in various periods after immunization (7, 14, 21, 30 and 60 days) to alter the testis following intravenous injection was studied in guinea-pigs. Only 30-day immune sera containing maximum antibodies to testicular antigens (fluorescent and spermacytotoxic) were able to induce alteration of the testis after preliminary (10 days before) intracutaneous administration of complete Freund's adjuvant. Within the first two days after the alteration induction, fixation of globulin from the immune serum on the structures of spermatozoas from the testis was determined by the immunofluorescent technique. Atrophy of the spermatogenic epithelium developed by the 7th day after the alteration induction. IgM containing spermatocytotoxic antibodies are responsible for the testis impairment induced by the spermatocytotoxic antibodies.
在豚鼠中研究了免疫后不同时期（7、14、21、30和60天）获得的同源抗链球菌血清经静脉注射后改变睾丸的能力。只有含有针对睾丸抗原（荧光和精子细胞毒性）的最大量抗体的30天免疫血清，在预先（提前10天）皮内注射完全弗氏佐剂后能够诱导睾丸改变。在诱导改变后的头两天内，通过免疫荧光技术确定免疫血清中的球蛋白在睾丸精子结构上的固定情况。诱导改变后第7天，生精上皮出现萎缩。含有精子细胞毒性抗体的IgM负责由精子细胞毒性抗体诱导的睾丸损伤。
