Ogurtsov R P, Zubzhitskiĭ Iu N
Arkh Patol. 1978;40(12):23-9.
Guinea pigs and mice develop orchitis after immunization with killed streptococcus groups A (type 12) cells in complete adjuvant. In guinea pigs the process is characterized by the atrophy of spermatogenous epithelium of the testicles, and in mice by the disappearance of mature spermia from convoluted seminiferous tubules. Globulin fixed on spermia was detected in testicles of the immunized mice. Guinea pigs and mouse sera contained antibodies reacting with spermatid and spermatozoid structures of normal testicles. Immunized guinea pigs showed positive reactions of blast-transformation of lymphocytes and skin reactions of the delayed type to testicle antigens. The development of orchitis in guinea pigs and mice correlates in time with the appearance of antibodies and the development of the delayed type hyperseusitivity to the testicle antigens.
豚鼠和小鼠在用完全佐剂中的灭活A组（12型）链球菌细胞免疫后会发生睾丸炎。在豚鼠中，该过程的特征是睾丸生精上皮萎缩，而在小鼠中则表现为曲细精管中成熟精子消失。在免疫小鼠的睾丸中检测到固定在精子上的球蛋白。豚鼠和小鼠血清中含有与正常睾丸的精子细胞和精子结构发生反应的抗体。免疫的豚鼠表现出淋巴细胞的 blast 转化阳性反应以及对睾丸抗原的迟发型皮肤反应。豚鼠和小鼠睾丸炎的发展在时间上与抗体的出现以及对睾丸抗原的迟发型超敏反应的发展相关。
