针对乙肝病毒衍生抗原的体液免疫和细胞免疫：弗氏完全佐剂、明矾和脂质体的比较活性。
Humoral and cellular immunity to hepatitis B virus-derived antigens: comparative activity of Freund complete adjuvant alum, and liposomes.
作者信息
Sanchez Y, Ionescu-Matiu I, Dreesman G R, Kramp W, Six H R, Hollinger F B, Melnick J L
出版信息
Infect Immun. 1980 Dec;30(3):728-33. doi: 10.1128/iai.30.3.728-733.1980.
Abstract
Complete Freud adjuvant, aluminum gel, and liposomes were compared for their ability to enhance the immunogenicity of an intact 22-nm HBsAg particle vaccine and an HBsAg-derived polypeptide vaccine in guinea pigs. Both humoral and cell-mediated immune responses were evaluated. The greatest immune response was obtained with complete Freund adjuvant, regardless of the antigen preparation. Aluminum gel appeared to be a better adjuvant for 22-nm HBsAg particles, but the liposomes rendered polypeptide preparations more immunogenic. The possibility that various proportions were entrapped in aqueous compartments instead of being inserted into the lipid bilayers of liposomes might account for this difference. The development of both humoral and cellular immunity was dependent upon the use of an adjuvant, because aqueous preparations had poor immunogenicity.
摘要
在豚鼠中，比较了完全弗氏佐剂、铝凝胶和脂质体增强完整22纳米乙肝表面抗原（HBsAg）颗粒疫苗和HBsAg衍生多肽疫苗免疫原性的能力。评估了体液免疫和细胞介导免疫反应。无论抗原制剂如何，完全弗氏佐剂产生的免疫反应最强。铝凝胶似乎是22纳米HBsAg颗粒的更好佐剂，但脂质体使多肽制剂更具免疫原性。不同比例的抗原被困在水相区室而不是插入脂质体的脂质双层中，这一可能性可能解释了这种差异。体液免疫和细胞免疫的发展均依赖于佐剂的使用，因为水性制剂的免疫原性较差。
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