急性胰腺炎患者针对肺炎支原体脂质抗原的免疫球蛋白M抗体反应。
Immunoglobulin M antibody response against Mycoplasma pneumoniae lipid antigen in patients with acute pancreatitis.
作者信息
Leinikki P O, Panzar P, Tykkä H
出版信息
J Clin Microbiol. 1978 Aug;8(2):113-8. doi: 10.1128/jcm.8.2.113-118.1978.
Abstract
Serial serum samples from patients with acute pancreatitis showed a significant increase in antibodies against methanol-chloroform-extracted lipid antigen from Mycoplasma pneumoniae when tested by complement fixation. The antibodies did not react with antigens prepared from other human mycoplasmas or from pancreatic tissue by lipid extraction. The antibodies were predominantly immunoglobulin M (IgM). No correlation with cold agglutinins or cardiolipid complement-fixing antibodies was found. The IgM antibody response seemed to be prolonged: after 3 to 4 weeks the antibodies were still in many cases exclusively IgM. Similar IgM responses were also found in certain cases of acute meningoencephalitis. We postulate that during the disease antigenic components identical or very similar to major determinants in the M. pneumoniae lipid antigen are revealed and elicit the IgM antibody response. Their resemblance to natural antibodies and their possible biological role is discussed.
摘要
对急性胰腺炎患者的系列血清样本进行补体结合试验检测时发现，其针对肺炎支原体经甲醇 - 氯仿提取的脂质抗原的抗体显著增加。这些抗体与从其他人类支原体或胰腺组织经脂质提取制备的抗原不发生反应。抗体主要为免疫球蛋白M（IgM）。未发现与冷凝集素或心磷脂补体结合抗体存在相关性。IgM抗体反应似乎持续时间较长：3至4周后，在许多情况下抗体仍仅为IgM。在某些急性脑膜脑炎病例中也发现了类似的IgM反应。我们推测，在疾病过程中，与肺炎支原体脂质抗原主要决定簇相同或非常相似的抗原成分被暴露，并引发了IgM抗体反应。文中讨论了它们与天然抗体的相似性及其可能的生物学作用。
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