Reeve P, Gerendas B, Moritz A, Liehl E, Kunz C, Hofmann H, Maassab H F
J Med Virol. 1980;6(1):75-83. doi: 10.1002/jmv.1890060110.
Two cold-recombinant influenza A (H1N1) viruses were tested in several groups of human volunteers. Only minor clinical symptoms were seen and no febrile reactions occurred. With serologically primed individuals virus shedding was low, but a high proportion showed rises in serum antibody levels after vaccination and mean titres were high. With serologically unprimed volunteers shedding was high, about 75% yielding viruses but only at low titres and for a short duration. No revertant viruses were found and there was no evidence of transmission to potentially susceptible individuals housed in close contact to the vaccinees. Serum antibody responses with unprimed volunteers were, however, low. Only about one half showed increases in serum antibody titres after vaccination and mean titres were low. Nevertheless, challenge with live attenuated virus indicated a high degree of protection based on virological evidence of infection.
两种冷重组甲型流感病毒（H1N1）在几组人类志愿者身上进行了测试。仅观察到轻微的临床症状，未出现发热反应。对于血清学上已致敏的个体，病毒排出量较低，但接种疫苗后，很大一部分人的血清抗体水平有所上升，且平均滴度较高。对于血清学上未致敏的志愿者，病毒排出量较高，约75%排出病毒，但滴度较低且持续时间较短。未发现回复病毒，也没有证据表明病毒传播给了与接种者密切接触的潜在易感个体。然而，未致敏志愿者的血清抗体反应较低。接种疫苗后，只有约一半的人血清抗体滴度有所增加，且平均滴度较低。尽管如此，基于感染的病毒学证据，用减毒活病毒进行攻击表明有高度的保护作用。
