接种冷适应甲型/香港/123/77（H1N1）重组病毒的血清阴性儿童的体液免疫和细胞免疫反应
Humoral and cellular immune responses of seronegative children vaccinated with a cold-adapted influenza A/HK/123/77 (H1N1) recombinant virus.
作者信息
Lazar A, Okabe N, Wright P F
出版信息
Infect Immun. 1980 Mar;27(3):862-6. doi: 10.1128/iai.27.3.862-866.1980.
Abstract
Humoral and cell-mediated immune responses of young, seronegative children were assessed after intranasal vaccination with a cold-adapted influenza. A/HK/77 (H1N1) CR 35 recombinant virus. Vaccines shedding influenza virus experienced a rise in hemagglutinin-inhibition antibody 15 to 30 days after vaccination. Vaccinees showed low but significant lymphocyte transformation to A/USSR (H1N1) by day 8 after vaccination, which decreased to prevaccination levels at 30 to 34 days. The lymphocyte transformation response occurred before serum antibody rises were detected by hemagglutinin-inhibition assay. No change in lymphocyte responsiveness was observed after vaccination as measured by phytohemagglutinin stimulation. Lymphocytes responded to in vitro incubation with inactivated influenza (H1N1) virus by producing interferon. The interferon produced was of type I and was observed in vaccinees and nonvaccinees both before and after vaccination.
摘要
对血清反应阴性的幼儿经鼻接种冷适应流感A/HK/77（H1N1）CR 35重组病毒疫苗后，评估其体液免疫和细胞介导的免疫反应。接种流感病毒疫苗后，血凝素抑制抗体在接种后15至30天出现上升。接种者在接种后第8天对A/USSR（H1N1）表现出低但显著的淋巴细胞转化，在30至34天时降至接种前水平。淋巴细胞转化反应在通过血凝素抑制试验检测到血清抗体升高之前就已发生。通过植物血凝素刺激测量，接种疫苗后未观察到淋巴细胞反应性的变化。淋巴细胞通过产生干扰素对与灭活流感（H1N1）病毒的体外孵育产生反应。所产生的干扰素为I型，在接种者和未接种者接种前和接种后均有观察到。
相似文献
1
Humoral and cellular immune responses of seronegative children vaccinated with a cold-adapted influenza A/HK/123/77 (H1N1) recombinant virus.接种冷适应甲型/香港/123/77（H1N1）重组病毒的血清阴性儿童的体液免疫和细胞免疫反应
Infect Immun. 1980 Mar;27(3):862-6. doi: 10.1128/iai.27.3.862-866.1980.
2
In vitro production of anti-influenza virus antibody after simultaneous administration of H3N2 and H1N1 cold-adapted vaccines in seronegative children.血清阴性儿童同时接种H3N2和H1N1冷适应疫苗后抗流感病毒抗体的体外产生
Vaccine. 1986 Mar;4(1):50-4. doi: 10.1016/0264-410x(86)90097-6.
3
Cold-recombinant influenza A/California/10/78 (H1N1) virus vaccine (CR-37) in seronegative children: infectivity and efficacy against investigational challenge.血清阴性儿童接种冷重组甲型流感病毒/加利福尼亚/10/78（H1N1）疫苗（CR-37）：对试验性攻击的感染性和有效性
J Infect Dis. 1984 May;149(5):735-40. doi: 10.1093/infdis/149.5.735.
4
Cell-mediated immune response of human lymphocytes to influenza A/USSR (H1N1) virus infection.人淋巴细胞对甲型流感病毒/苏联株（H1N1）感染的细胞介导免疫反应。
Infect Immun. 1980 Mar;27(3):867-71. doi: 10.1128/iai.27.3.867-871.1980.
5
Studies in man with cold-recombinant influenza virus (H1N1) live vaccines.关于人用冷重组流感病毒（H1N1）活疫苗的研究。
J Med Virol. 1980;6(1):75-83. doi: 10.1002/jmv.1890060110.
6
Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults.血清反应阳性成人中减毒活甲型H1N1和H3N2流感病毒疫苗的使用。
J Clin Microbiol. 1990 Mar;28(3):596-9. doi: 10.1128/jcm.28.3.596-599.1990.
7
Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.接种由A/列宁格勒/134/57儿科冷适应供体毒株制备的A/巴西/11/78（H1N1）样重组流感病毒的学童的类特异性抗体反应。
Vaccine. 1988 Feb;6(1):25-8. doi: 10.1016/0264-410x(88)90009-6.
8
Immunization of infants and young children with live attenuated trivalent cold-recombinant influenza A H1N1, H3N2, and B vaccine.用减毒活三价冷重组甲型H1N1、H3N2和乙型流感疫苗对婴幼儿进行免疫接种。
J Infect Dis. 1992 Apr;165(4):727-32. doi: 10.1093/infdis/165.4.727.
9
Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers.甲型流感病毒/香港/123/77（H1N1）ts-1A2及冷适应重组病毒在血清阴性成年志愿者中的评估。
Infect Immun. 1980 Aug;29(2):348-55. doi: 10.1128/iai.29.2.348-355.1980.
10
Reduced infectivity of cold-adapted influenza A H1N1 viruses in the elderly: correlation with serum and local antibodies.减毒甲型H1N1流感病毒在老年人中的感染力降低：与血清及局部抗体的相关性
J Am Geriatr Soc. 1992 Feb;40(2):163-7. doi: 10.1111/j.1532-5415.1992.tb01938.x.
引用本文的文献
1
An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats.一种基于甲病毒复制子的人偏肺病毒疫苗在小鼠和棉鼠中具有免疫原性且具有保护作用。
J Virol. 2008 Nov;82(22):11410-8. doi: 10.1128/JVI.01688-08. Epub 2008 Sep 10.
2
Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats.编码呼吸道合胞病毒表面糖蛋白的委内瑞拉马脑炎病毒复制子颗粒可在小鼠和棉鼠中诱导保护性黏膜反应。
J Virol. 2007 Dec;81(24):13710-22. doi: 10.1128/JVI.01351-07. Epub 2007 Oct 10.
3
Effectiveness of reverse transcription-PCR, virus isolation, and enzyme-linked immunosorbent assay for diagnosis of influenza A virus infection in different age groups.逆转录聚合酶链反应、病毒分离和酶联免疫吸附测定法在不同年龄组甲型流感病毒感染诊断中的有效性。
J Clin Microbiol. 2002 Jun;40(6):2051-6. doi: 10.1128/JCM.40.6.2051-2056.2002.
4
Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines.感染减毒活甲型流感病毒疫苗的儿童的分泌性和全身性免疫反应。
Infect Immun. 1982 Jun;36(3):1102-8. doi: 10.1128/iai.36.3.1102-1108.1982.
5
Dose response of A/Alaska/6/77 (H3N2) cold-adapted reassortant vaccine virus in adult volunteers: role of local antibody in resistance to infection with vaccine virus.A/阿拉斯加/6/77（H3N2）冷适应重配疫苗病毒在成年志愿者中的剂量反应：局部抗体在抵抗疫苗病毒感染中的作用
Infect Immun. 1983 Jun;40(3):1044-51. doi: 10.1128/iai.40.3.1044-1051.1983.
6
Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers.甲型流感病毒冷适应重配活疫苗CR-37（H1N1）在日本成年志愿者中的血清学评估。
J Hyg (Lond). 1984 Apr;92(2):231-42. doi: 10.1017/s0022172400064251.
7
Serum neutralizing antibody and lymphocyte transformation responses after influenza B virus infections.乙型流感病毒感染后的血清中和抗体及淋巴细胞转化反应。
J Clin Microbiol. 1983 Nov;18(5):1266-8. doi: 10.1128/jcm.18.5.1266-1268.1983.
8
Attenuation of wild-type human influenza A virus by acquisition of the PA polymerase and matrix protein genes of influenza A/Ann Arbor/6/60 cold-adapted donor virus.通过获取甲型流感病毒/安阿伯/6/60冷适应供体病毒的PA聚合酶基因和基质蛋白基因来减毒野生型人类甲型流感病毒。
J Clin Microbiol. 1985 Nov;22(5):719-25. doi: 10.1128/jcm.22.5.719-725.1985.
9
Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine.接种减毒活流感 A 病毒疫苗或灭活流感 A 病毒疫苗的成年人中局部和全身抗体反应的产生及持续情况。
J Clin Microbiol. 1986 Jan;23(1):66-72. doi: 10.1128/jcm.23.1.66-72.1986.
10
New aspects of influenza viruses.流感病毒的新方面
Clin Microbiol Rev. 1992 Jan;5(1):74-92. doi: 10.1128/CMR.5.1.74.
本文引用的文献
1
Immunosuppression during influenza virus infection.流感病毒感染期间的免疫抑制。
Infect Immun. 1974 Nov;10(5):996-1002. doi: 10.1128/iai.10.5.996-1002.1974.
2
Low-Temperature-Adapted Influenza A2/AA/6/60 Virus Vaccine in Man.低温适应型甲型流感病毒 A2/AA/6/60 疫苗在人体中的应用。
Infect Immun. 1973 Jan;7(1):119-22. doi: 10.1128/iai.7.1.119-122.1973.
3
Adaptation and growth characteristics of influenza virus at 25 degrees c.流感病毒在25摄氏度下的适应与生长特性
Nature. 1967 Feb 11;213(5076):612-4. doi: 10.1038/213612a0.
4
Biologic and immunologic characteristics of cold-adapted influenza virus.冷适应流感病毒的生物学和免疫学特性
J Immunol. 1969 Mar;102(3):728-32.
5
Production of interferon in volunteers infected with Asian influenza.感染亚洲流感的志愿者体内干扰素的产生
J Infect Dis. 1970 Apr;121(4):419-26. doi: 10.1093/infdis/121.4.419.
6
A comparative study of attenuated influenza viruses.减毒流感病毒的比较研究
Bull World Health Organ. 1971;44(5):593-8.
7
Effect of virus infections on the function of the immune system.病毒感染对免疫系统功能的影响。
Annu Rev Microbiol. 1970;24:525-38. doi: 10.1146/annurev.mi.24.100170.002521.
8
Humoral and cellular response in humans after immunization with influenza vaccine.人类接种流感疫苗后的体液和细胞反应。
Infect Immun. 1973 Apr;7(4):594-6. doi: 10.1128/iai.7.4.594-596.1973.
9
Temperature-sensitive mutants of influenza virus. IV. Induction of interferon in the nasopharynx by wild-type and a temperature-sensitive recombinant virus.流感病毒的温度敏感突变体。IV. 野生型和温度敏感重组病毒在鼻咽部诱导干扰素的情况。
J Infect Dis. 1973 Oct;128(4):488-93. doi: 10.1093/infdis/128.4.488.
10
Decreased skin-test reactivity associated with influenza.与流感相关的皮肤试验反应性降低。
J Infect Dis. 1972 Apr;125(4):398-402. doi: 10.1093/infdis/125.4.398.
Zotero 插件