Baranov V G, Propp M V, Sokoloverova I M, Savchenko O N, Onegova R F
Probl Endokrinol (Mosk). 1981 Mar-Apr;27(2):44-8.
The hypophysis weight significantly rises in male and female rats suffering from mild alloxan diabetes (prediabetes and the latent disease form). In pronounced diabetes, a decrease in the hypophysis weight is seen. These changes do not correlate with alterations in sex function which is essentially deranged only in pronounced diabetes mellitus when the blood levels of luteinizing hormone (LH), testosterone and estradiol are reduced and the weight of the reproductive organs (prostate and uterus), dependent on the above blood hormone levels, decreases. These indices remain unchanged in prediabetes and the latent diabetes form. In marked diabetes, a rise in gonadotropin-releasing hormone level in the hypothalamic arcuate body is seen that may be indicative of lowering gonadotropin-releasing hormone secretion into the blood rather than of its synthesis reduction in peptiergic neurons. These disturbances are supposed to be primary link in sex dysfunction development in diabetes.
轻度四氧嘧啶糖尿病（糖尿病前期和潜伏疾病形式）的雄性和雌性大鼠垂体重量显著增加。在严重糖尿病中，可见垂体重量减轻。这些变化与性功能改变无关，性功能仅在严重糖尿病时才基本紊乱，此时促黄体生成素（LH）、睾酮和雌二醇的血液水平降低，依赖于上述血液激素水平的生殖器官（前列腺和子宫）重量减轻。这些指标在糖尿病前期和潜伏糖尿病形式中保持不变。在严重糖尿病中，下丘脑弓状体内促性腺激素释放激素水平升高，这可能表明促性腺激素释放激素分泌入血减少，而不是肽能神经元中其合成减少。这些紊乱被认为是糖尿病性功能障碍发展的主要环节。
