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成年小鼠脾细胞的同种异型抑制

Allotypic suppression of adult mouse spleen cells.

作者信息

Anderson H R

出版信息

Immunology. 1970 Jul;19(1):169-79.

PMID:4922028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455615/
Abstract

Adult mouse spleen cells were transferred into irradiated adult mice with xenogeneic erythrocytes. Antibody-producing cells were measured by the localized haemolysis in gel (LHG) assay. Anti-allotype serum directed against the γG allotype of the donor cells, given to the recipients at the same time as antigen and spleen cells, suppressed the plaque-forming cells (PFC) producing antibody of that allotype, and had little effect on the other classes investigated.

摘要

将成年小鼠的脾细胞转移到经照射的带有异种红细胞的成年小鼠体内。通过凝胶中的局部溶血（LHG）试验来测定产生抗体的细胞。在给予受体抗原和脾细胞的同时，给予针对供体细胞γG同种异型的抗同种异型血清，可抑制产生该同种异型抗体的空斑形成细胞（PFC），而对所研究的其他类别影响很小。

相似文献

1
Allotypic suppression of adult mouse spleen cells.成年小鼠脾细胞的同种异型抑制
Immunology. 1970 Jul;19(1):169-79.
2
Inhibition of the immune response of mouse spleen cells to sheep erythrocytes in vitro by anti-immunoglobulin sera.抗免疫球蛋白血清对小鼠脾细胞体外抗绵羊红细胞免疫反应的抑制作用。
Eur J Immunol. 1971 Jun;1(3):157-62. doi: 10.1002/eji.1830010303.
3
Immune responses in aged mice: changes of antibody-forming cell precursors and antigen-reactive cells with ageing.老年小鼠的免疫反应：抗体形成细胞前体和抗原反应性细胞随衰老的变化。
Clin Exp Immunol. 1971 Jun;8(6):957-62.
4
The effect of x-irradiation of the appearance of antibody-forming cells in the mouse spleen following the injection of sheep erythrocytes.注射绵羊红细胞后，X射线照射对小鼠脾脏中抗体形成细胞出现的影响。
Eur J Immunol. 1973 Nov;3(11):698-703. doi: 10.1002/eji.1830031109.
5
Effect of host-versus-graft and graft-versus-host reactions on the immune response of mice to sheep red blood cells.宿主抗移植物反应和移植物抗宿主反应对小鼠针对绵羊红细胞的免疫应答的影响。
Folia Biol (Praha). 1971;17(2):111-22.
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Immunology. 1973 Aug;25(2):158-96.
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Antibody formation by bone marrow cells in irradiated mice. I. Thymus-dependent and thymus-independent responses to sheep erythrocytes.受照射小鼠骨髓细胞的抗体形成。I. 对绵羊红细胞的胸腺依赖性和非胸腺依赖性反应。
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Allotypic suppression of adult mouse spleen cells: cell differentiation, class restriction and allotypic exclusion.
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Antibody-mediated suppression of the immune response: effect on the development of immunologic memory.抗体介导的免疫反应抑制：对免疫记忆形成的影响。
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Cells involved in the immune response. XIV. The immunologic response of irradiated rabbits given allogeneic bone marrow cells incubated with antigen and-or subjected to irradiation in vitro.参与免疫反应的细胞。十四、经体外与抗原孵育和/或照射的同种异体骨髓细胞对受照射兔的免疫反应。
J Immunol. 1970 Apr;104(4):1009-15.

引用本文的文献

1
Allotype suppression of the responsiveness of adoptively transferred adult spleen cells induced by affinity prepared anti-allotype antibody.亲和制备的抗同种异型抗体诱导的过继转移成年脾细胞反应性的同种异型抑制。
Immunology. 1981 Apr;42(4):601-10.
2
Allotype suppression in an adoptive transfer system in adult mice: the specificity and feedback effects of a monoclonal IgG3 anti-(Igh-1b) allotype antibody.成年小鼠过继转移系统中的同种异型抑制：单克隆IgG3抗-（Igh-1b）同种异型抗体的特异性及反馈效应
Immunology. 1984 Mar;51(3):511-6.
3
Active suppression of immunoglobulin allotype synthesis. I. Chronic suppression after perinatal exposure to maternal antibody to paternal allotype in (SJL x BALB-c)F 1 mice.免疫球蛋白同种异型合成的主动抑制。I. 围产期暴露于母体抗父本同种异型抗体后，(SJL×BALB-c)F1小鼠的慢性抑制。
J Exp Med. 1972 May 1;135(5):1151-62. doi: 10.1084/jem.135.5.1151.
4
The relationship between the immunoglobulin class of B-cell precursors and the degree of synergism obtained from the presence of T cells.B细胞前体的免疫球蛋白类别与T细胞存在所产生的协同作用程度之间的关系。
Clin Exp Immunol. 1974 Mar;16(3):393-400.
5
Conditions for the development of IgM- and IgG-antibody-secreting cells from primed mouse splenocytes in vitro.体外从小鼠致敏脾细胞发育IgM和IgG抗体分泌细胞的条件。
Immunology. 1977 May;32(5):793-801.

本文引用的文献

1
A CHROMOSOME REGION FOR GAMMA 2A AND BETA 2A GLOBULIN H CHAIN ISOANTIGENS IN THE MOUSE.小鼠中γ2A和β2A球蛋白重链同种抗原的一个染色体区域。
Cold Spring Harb Symp Quant Biol. 1964;29:455-62. doi: 10.1101/sqb.1964.029.01.048.
2
Effect of maternal isoantibodies on the quantitative expression of two allelic genes controlling gamma-globulin allotypic specificities.母体同种抗体对控制γ-球蛋白同种异型特异性的两个等位基因定量表达的影响。
Nature. 1962 Aug 18;195:677-80. doi: 10.1038/195677a0.
3
Congenic mouse strains with different immunoglobulin allotypes. I. Breeding scheme, histocompatibility tests, and kinetics of gamma G2a-globulin production by transferred cells for C3H.SW and its congenic partner CWB/5.具有不同免疫球蛋白同种异型的同类系小鼠品系。I. C3H.SW及其同类系伙伴CWB/5的繁殖方案、组织相容性测试以及转移细胞产生γG2a球蛋白的动力学。
Transplantation. 1967 Nov;5(6):1484-95. doi: 10.1097/00007890-196711000-00013.
4
Antibody production studied by means of the LHG assay. I. The splenic response of CBA mice to sheep erythrocytes.通过淋巴细胞转化试验研究抗体产生。I. CBA小鼠对绵羊红细胞的脾脏反应。
Immunology. 1966 Dec;11(6):603-16.
5
Studies on rabbit lymphocytes in vitro. 8. The relationship between heterozygosity and homozygosity of lymphocyte donor and per cent blast transformation induced by antiallotype sera.家兔淋巴细胞的体外研究。8. 淋巴细胞供体的杂合性与纯合性以及抗同种异型血清诱导的母细胞转化百分比之间的关系。
J Exp Med. 1968 Jun 1;127(6):1139-48. doi: 10.1084/jem.127.6.1139.
6
Antibody production studied by means of the localized haemolysis in gel (LHG) assay. II. Assay procedure.通过凝胶内局部溶血法（LHG 测定法）研究抗体产生。II. 测定程序。
Immunology. 1968 Jan;14(1):69-79.
7
The use of subcellular fractions to raise anti-lymphocytic serum.利用亚细胞组分制备抗淋巴细胞血清。
Immunology. 1968 Oct;15(4):571-80.
8
Suppression of heavy and light chain allotypic expression in homozygous rabbits through embryo transfer.通过胚胎移植抑制纯合兔重链和轻链同种异型表达。
Proc Natl Acad Sci U S A. 1969 Mar;62(3):860-6. doi: 10.1073/pnas.62.3.860.
9
Antibody production studied by means of the localized haemolysis in gel (LHG) assay. 3. Mouse cells producing five different classes of antibody.通过凝胶局部溶血（LHG）试验研究抗体产生。3. 产生五种不同类别抗体的小鼠细胞。
Immunology. 1969 Jul;17(1):93-110.
10
Studies on rabbit lymphocytes in vitro. IX. The suppression of antiallotype-induced blast transformation in lymphocyte cultures from allotypically suppressed donors.兔淋巴细胞的体外研究。IX. 来自同种异型抑制供体的淋巴细胞培养物中抗同种异型诱导的母细胞转化的抑制
J Exp Med. 1968 Aug 1;128(2):341-55. doi: 10.1084/jem.128.2.341.