Anderson H R
Immunology. 1970 Jul;19(1):169-79.
Adult mouse spleen cells were transferred into irradiated adult mice with xenogeneic erythrocytes. Antibody-producing cells were measured by the localized haemolysis in gel (LHG) assay. Anti-allotype serum directed against the γG allotype of the donor cells, given to the recipients at the same time as antigen and spleen cells, suppressed the plaque-forming cells (PFC) producing antibody of that allotype, and had little effect on the other classes investigated.
将成年小鼠的脾细胞转移到经照射的带有异种红细胞的成年小鼠体内。通过凝胶中的局部溶血(LHG)试验来测定产生抗体的细胞。在给予受体抗原和脾细胞的同时,给予针对供体细胞γG同种异型的抗同种异型血清,可抑制产生该同种异型抗体的空斑形成细胞(PFC),而对所研究的其他类别影响很小。