使用抗生素清除装置进行体外血液中抗生素清除及细菌回收
In vitro antibiotic removal and bacterial recovery from blood with an antibiotic removal device.
作者信息
Lindsey N J, Riely P E
出版信息
J Clin Microbiol. 1981 Mar;13(3):503-7. doi: 10.1128/jcm.13.3.503-507.1981.
Abstract
The antibiotic removal device manufactured by Marion Laboratories (Kansas City., Mo.) is intended for treatment, before culture, of blood specimens from hospital patients being treated with antibiotics. Measurement of 13 antibiotics showed that the antibiotic removal device removed amikacin, ampicillin, carbenicillin, cefazolin, cephalothin, chloramphenicol, gentamicin, nafcillin, tetracycline, tobramycin, and vancomycin and reduced cefoxitin and ticarcillin to extremely low levels. Three combinations of antibiotics were similarly removed or reduced. Five species of anaerobic bacteria, one yeast species, and six species of facultative or aerobic bacteria were used to challenge the possibility that the antibiotic removal device would trap or inhibit microorganisms. All were recovered from the device in the same numbers as were inoculated.
摘要
马里恩实验室（密苏里州堪萨斯城）生产的抗生素去除装置旨在对正在接受抗生素治疗的医院患者的血样进行培养前处理。对13种抗生素的检测表明，该抗生素去除装置能去除阿米卡星、氨苄西林、羧苄西林、头孢唑林、头孢噻吩、氯霉素、庆大霉素、萘夫西林、四环素、妥布霉素和万古霉素，并将头孢西丁和替卡西林降至极低水平。三种抗生素组合也同样被去除或减少。使用五种厌氧菌、一种酵母菌以及六种兼性菌或需氧菌来检验抗生素去除装置是否会截留或抑制微生物的可能性。所有这些微生物从该装置中回收的数量与接种时的数量相同。
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