使用抗菌剂去除装置从败血症患者中快速分离细菌。
Rapid isolation of bacteria from septicemic patients by use of an antimicrobial agent removal device.
作者信息
Wallis C, Melnick J L, Wende R D, Riely P E
出版信息
J Clin Microbiol. 1980 May;11(5):462-4. doi: 10.1128/jcm.11.5.462-464.1980.
The new Antimicrobial Removal Device increased the efficacy of conventional methods for isolating bacteria from the blood of septicemic patients. The device removes as much as 100 microgram of antibiotics per ml from whole blood without a significant decrease in bacteria. Of 51 patients studied, 31 yielded positive cultures, and the Antimicrobial Removal Device permitted earlier isolation of the causative agent from blood. Subcultured within the first 12 h yielded 12 positive isolates, as the 31 agents were isolated more rapidly after Antimicrobial Removal Device permitted earlier isolation of the causative agent from blood. Subcultures within the first 12 h yielded 12 positive isolates, as compared to 2 when subcultured without processing in the device. Overall, 21 of the 31 agents were isolated more rapidly after Antimicrobial Removal Device treatment, and four samples were positive only after such treatment. One agent was not isolated in the treated culture.
新型抗菌去除装置提高了从败血症患者血液中分离细菌的传统方法的功效。该装置每毫升全血可去除多达100微克抗生素，而细菌数量无显著减少。在研究的51例患者中，31例培养结果呈阳性，抗菌去除装置使致病因子能更早地从血液中分离出来。在最初12小时内进行传代培养产生了12株阳性分离株，因为在抗菌去除装置使致病因子能更早地从血液中分离出来后，这31种病原体被更快地分离出来。与未在该装置中处理就进行传代培养时得到2株阳性分离株相比，在最初12小时内进行传代培养产生了12株阳性分离株。总体而言，31种病原体中有21种在经过抗菌去除装置处理后被更快地分离出来，4份样本仅在经过此类处理后呈阳性。有一种病原体在处理后的培养物中未被分离出来。
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