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[左旋咪唑在班氏丝虫病中的应用]

[Use of levamisole in W. bancrofti filariasis].

作者信息

Pérez Avila J, Lastre González M, Lazo Lopetegui O, Montalvo Alvarez G

出版信息

Rev Cubana Med Trop. 1980 Sep-Dec;32(3):185-90.

PMID:7017841
Abstract

16 african patients with diagnosed W. bancroft's filariasis admitted to Pedro Kourí Tropical Medicine Institute were subjected to a therapeutic management with levamisole: 300 mg as starting dosage, and 150 mg/day for seven days. 11 patients had been previously treated with several courses of diethylcarbamazine (DEC), but a low microfilaremia persisted in them. In the other 5 patients the only medication used was levamisole. A rapid fall in microfilaria concentrations was found from the first day of treatment on in all patients. Eventually, 14 patients (87,5%) were negative and two patients (12,5%) persisted having low microfilaremia and their concentrations lowered by 89 ad 93% respectively.

摘要

16名被诊断为班氏吴策线虫病的非洲患者入住佩德罗·库里热带医学研究所,接受了左旋咪唑治疗:起始剂量为300毫克,之后每日150毫克,持续7天。11名患者此前接受过多个疗程的乙胺嗪(DEC)治疗,但仍有低水平的微丝蚴血症。另外5名患者仅使用了左旋咪唑。从治疗第一天起,所有患者的微丝蚴浓度均迅速下降。最终,14名患者(87.5%)检测结果呈阴性,两名患者(12.5%)仍有低水平的微丝蚴血症,其微丝蚴浓度分别降低了89%和93%。

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