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[左旋咪唑在班氏丝虫病中的应用]

[Use of levamisole in W. bancrofti filariasis].

作者信息

Pérez Avila J, Lastre González M, Lazo Lopetegui O, Montalvo Alvarez G

出版信息

Rev Cubana Med Trop. 1980 Sep-Dec;32(3):185-90.

PMID:7017841
Abstract

16 african patients with diagnosed W. bancroft's filariasis admitted to Pedro Kourí Tropical Medicine Institute were subjected to a therapeutic management with levamisole: 300 mg as starting dosage, and 150 mg/day for seven days. 11 patients had been previously treated with several courses of diethylcarbamazine (DEC), but a low microfilaremia persisted in them. In the other 5 patients the only medication used was levamisole. A rapid fall in microfilaria concentrations was found from the first day of treatment on in all patients. Eventually, 14 patients (87,5%) were negative and two patients (12,5%) persisted having low microfilaremia and their concentrations lowered by 89 ad 93% respectively.

摘要

16名被诊断为班氏吴策线虫病的非洲患者入住佩德罗·库里热带医学研究所,接受了左旋咪唑治疗:起始剂量为300毫克,之后每日150毫克,持续7天。11名患者此前接受过多个疗程的乙胺嗪(DEC)治疗,但仍有低水平的微丝蚴血症。另外5名患者仅使用了左旋咪唑。从治疗第一天起,所有患者的微丝蚴浓度均迅速下降。最终,14名患者(87.5%)检测结果呈阴性,两名患者(12.5%)仍有低水平的微丝蚴血症,其微丝蚴浓度分别降低了89%和93%。

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1
[Use of levamisole in W. bancrofti filariasis].[左旋咪唑在班氏丝虫病中的应用]
Rev Cubana Med Trop. 1980 Sep-Dec;32(3):185-90.
2
[Activity of levamisole (Solaskil) in lymphatic filariasis caused by Wucheria bancrofti (variety pacifica].
Bull Soc Pathol Exot Filiales. 1976 May-Jun;69(3):257-65.
3
Levamisole and mebendazole in the treatment of bancroftian infection.左旋咪唑和甲苯咪唑治疗班氏丝虫感染
Southeast Asian J Trop Med Public Health. 1978 Dec;9(4):571-5.
4
Chemotherapy with spaced doses of diethylcarbamazine preceded by levamisole on Bancroftian filariasis.
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5
Persistence of microfilaremia in bancroftian filariasis after diethylcarbamazine citrate therapy.枸橼酸乙胺嗪治疗后班氏丝虫病微丝蚴血症的持续存在情况。
Trop Med Parasitol. 1988 Jun;39(2):128-30.
6
Preliminary screening of antifilarial activity of levamisole and amodiaquine on Wuchereria bancrofti.左旋咪唑和阿莫地喹对班氏吴策线虫抗丝虫活性的初步筛选
Ann Trop Med Parasitol. 1979 Oct;73(5):465-72. doi: 10.1080/00034983.1979.11687286.
7
Drug trials with levamisole hydrochloride and diethylcarbamazine citrate in Bancroftian and Malayan filariasis.盐酸左旋咪唑和枸橼酸乙胺嗪治疗班氏丝虫病和马来丝虫病的药物试验。
Trans R Soc Trop Med Hyg. 1980;74(3):285-91. doi: 10.1016/0035-9203(80)90081-4.
8
Chemotherapy with diethylcarbamazine and levamisole in Bancroftian filariasis.乙胺嗪和左旋咪唑联合化疗治疗班氏丝虫病
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Bull Soc Pathol Exot Filiales. 1979 Sep-Dec;72(5-6):471-81.
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