McMahon J E
Ann Trop Med Parasitol. 1979 Oct;73(5):465-72. doi: 10.1080/00034983.1979.11687286.
A single dose of levamisole of 3 mg/kg had a marked microfilaricidal effect in some persons harbouring Wuchereria bancrofti, but there was considerable variation in the response. In some cases blood examinations for microfilariae remained negative or at a low level for several months. Persons with high pretreatment microfilaraemias responded less to therapy than did those with low counts. The main side-reaction to levamisole was fever, which began six to eight hours after treatment. Combined DEC-levamisole therapy appears to have no advantage over the use of DEC alone. Amodiaquine in a total dose of 40 mg/kg appears to be macrofilaricidal, but because of the slight possibility of blood dyscrasias, mass chemotherapy with this dosage could not be recommended. Some amodiaquine congeners shown to be effective in experimental infections against adult filarial worms may prove to have a higher chemotherapeutic index than amodiaquine against W. bancrofti in man.
单次服用3毫克/千克的左旋咪唑对一些感染班氏吴策线虫的人有显著的杀微丝蚴作用，但反应存在相当大的差异。在某些情况下，微丝蚴血液检查在几个月内仍为阴性或处于低水平。治疗前微丝蚴血症水平高的人对治疗的反应比计数低的人小。左旋咪唑的主要副作用是发热，在治疗后6至8小时开始。乙胺嗪-左旋咪唑联合疗法似乎并不比单独使用乙胺嗪有优势。总剂量为40毫克/千克的阿莫地喹似乎有杀成虫作用，但由于有轻微的血液系统疾病风险，不建议使用此剂量进行大规模化疗。一些在实验感染中对成年丝虫有效的阿莫地喹同系物，可能被证明在治疗人类班氏吴策线虫方面比阿莫地喹具有更高的化疗指数。
