生物蝶呤辅因子生物合成：肾上腺髓质和皮质中鸟苷三磷酸环化水解酶的独立调节。
Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex.
作者信息
Viveros O H, Lee C L, Abou-Donia M M, Nixon J C, Nichol C A
出版信息
Science. 1981 Jul 17;213(4505):349-50. doi: 10.1126/science.7017928.
PMID:7017928
Abstract
Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectively, whereas cycloheximide presents the increase in both tissues. These results provide evidence for induction and regulation of guanosine triphosphate cyclohydrolase.
摘要
鸟苷三磷酸环化水解酶是生物蝶呤生物合成中明显的限速酶，在用胰岛素或利血平处理的大鼠肾上腺皮质和髓质中其含量增加。去神经支配和垂体切除分别阻断了髓质和皮质酶活性的增加，而环己酰亚胺则抑制了这两个组织中的酶活性增加。这些结果为鸟苷三磷酸环化水解酶的诱导和调节提供了证据。
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