Craswell P W, Hird V M, Judd P A, Baillod R A, Varghese Z, Moorhead J F
Br Med J. 1972 Dec 30;4(5843):749-53. doi: 10.1136/bmj.4.5843.749.
Blood pressure, plasma renin activity, plasma sodium concentration, plasma potassium concentration, dietary sodium intake, and duration of dialysis have been measured under standard conditions in 89 patients on maintenance haemodialysis. No significant relation was found between plasma renin activity and blood pressure. Statistically significant correlations were found between plasma renin activity and plasma sodium concentration and between plasma renin activity and dietary sodium intake.Only one patient was found to have uncontrollable hypertension associated with a markedly raised plasma renin activity. Reasons are given for not performing bilateral nephrectomy in this patient. We believe the low incidence of uncontrollable hypertension and hyperreninaemia in our patients to be due to their slow introduction to haemodialysis, thus preventing violent swings in body weight, blood pressure, and renin secretion.Although plasma renin activity did fall with duration of dialysis, all 15 patients who have been on maintenance dialysis for longer than five years have normal levels.
在标准条件下，对89例维持性血液透析患者测量了血压、血浆肾素活性、血浆钠浓度、血浆钾浓度、饮食钠摄入量和透析时间。未发现血浆肾素活性与血压之间存在显著关系。发现血浆肾素活性与血浆钠浓度以及血浆肾素活性与饮食钠摄入量之间存在统计学上的显著相关性。仅发现1例患者患有与血浆肾素活性明显升高相关的难以控制的高血压。给出了未对该患者实施双侧肾切除术的原因。我们认为，我们的患者中难以控制的高血压和高肾素血症发生率低是由于他们缓慢开始血液透析，从而避免了体重、血压和肾素分泌的剧烈波动。尽管血浆肾素活性确实随着透析时间的延长而下降，但所有接受维持性透析超过5年的15例患者的血浆肾素活性水平均正常。
