Helldén L, Camosci D, Hock J, Tinanoff N
J Clin Periodontol. 1981 Feb;8(1):12-6. doi: 10.1111/j.1600-051x.1981.tb02019.x.
A clinical study was conducted on four adults to compare the relative efficacy of 0.2% chlorhexidine digluconate and 0.1% stannous fluoride (SnF2). Using a crossover experimental design, subjects rinsed twice daily for 5 days with SnF2 and then, after a 2-day interim recovery period, for 5 days with chlorhexidine. Statistically significant differences (P less than 0.05) in the relative efficacy of the two agents were found. Chlorhexidine was more effective in reducing Gingival and Plaque Indices, plaque wet weight and bacterial Colony Forming Units, calculated both per subject and per group.
对四名成年人进行了一项临床研究，以比较0.2%葡萄糖酸氯己定和0.1%氟化亚锡（SnF2）的相对疗效。采用交叉实验设计，受试者每天用SnF2漱口两次，持续5天，然后在2天的中期恢复期后，用氯己定漱口5天。发现两种药物的相对疗效存在统计学显著差异（P小于0.05）。氯己定在降低牙龈指数和菌斑指数、菌斑湿重以及细菌菌落形成单位方面更有效，这些指标均按每位受试者和每组进行计算。
