Sack D A, Kaminsky D C, Sack R B, Itotia J N, Arthur R R, Kapikian A Z, Orskov F, Orskov I
N Engl J Med. 1978 Apr 6;298(14):758-63. doi: 10.1056/NEJM197804062981402.
We performed a randomized double-blind study to determine the efficacy of doxycycline (100 mg daily) in preventing travelers' diarrhea among 39 Peace Corps volunteers during their first five weeks in Kenya. The volunteers took either doxycycline or placebo for three weeks and were observed for an additional two weeks. Nine of 21 taking placebo and one of 18 taking doxycycline had travelers' diarrhea during the treatment period (P = 0.012). The protection seemed to persist for at least one week after the drug was stopped. Enterotoxigenic Escherichia coli was the only pathogen isolated from the placebo group, but was not detected in persons taking doxycycline. None of these organisms were resistant to doxycycline or tetracycline, whereas resistance to tetracyclines and other antibiotics was common among the nonenterotoxigenic Esch. coli. We conclude that doxycycline effectively prevented most episodes of travelers' dirrhea.
我们进行了一项随机双盲研究，以确定多西环素（每日100毫克）在39名和平队志愿者在肯尼亚的头五周预防旅行者腹泻方面的疗效。志愿者服用多西环素或安慰剂三周，并额外观察两周。服用安慰剂的21人中有9人，服用多西环素的18人中有1人在治疗期间出现旅行者腹泻（P = 0.012）。停药后这种保护作用似乎至少持续了一周。产肠毒素大肠杆菌是从安慰剂组中分离出的唯一病原体，但在服用多西环素的人中未检测到。这些微生物均对多西环素或四环素不耐药，而在非产肠毒素大肠杆菌中对四环素和其他抗生素耐药很常见。我们得出结论，多西环素有效地预防了大多数旅行者腹泻发作。
