Sivarajan E S, Bruce R A, Almes M J, Green B, Bélanger L, Lindskog B D, Newton K M, Mansfield L W
N Engl J Med. 1981 Aug 13;305(7):357-62. doi: 10.1056/NEJM198108133050701.
Prolonged bed rest after myocardial infarction is thought to result in deconditioning, manifested by increased heart-rate and blood-pressure responses to exercise and decreased functional capacity. We studied the effects of early, supervised exercises in preventing deconditioning after acute myocardial infarction. Eighty-four patients were randomized to a control group and 174 to an exercise group. Enrollment in the exercise program occurred an average of 4.5 days after admission (range, one to nine). Discharge from the hospital occurred an average of 10.3 days after admission in the control group and 10.4 days in the exercise group. Most patients had a low-level treadmill test on the day before hospital discharge. There were no differences between the two groups in the clinical, hemodynamic, or electrocardiographic responses to the treadmill test. Incidences of complications and deaths (one death in each group) during hospitalization were not significantly different in the two groups, although six patients (3 per cent, all in the exercise group) required cardiac surgery--four because of recurrent chest pain and two because of rupture of heart muscle. Thus, we were unable to demonstrate any significant beneficial or deleterious effects of an early, in-hospital exercise program.
心肌梗死后长期卧床休息被认为会导致身体机能下降,表现为运动时心率和血压反应增加以及功能能力下降。我们研究了早期在监督下进行运动对预防急性心肌梗死后身体机能下降的影响。84例患者被随机分为对照组,174例被分为运动组。运动计划的参与平均在入院后4.5天(范围为1至9天)开始。对照组平均在入院后10.3天出院,运动组平均在入院后10.4天出院。大多数患者在出院前一天进行了低水平的跑步机测试。两组在跑步机测试的临床、血流动力学或心电图反应方面没有差异。住院期间两组的并发症和死亡发生率(每组各有1例死亡)没有显著差异,尽管有6例患者(3%,均在运动组)需要进行心脏手术——4例是因为复发性胸痛,2例是因为心肌破裂。因此,我们无法证明早期住院运动计划有任何显著的有益或有害影响。