霍乱毒素的作用以及霍乱的预防与治疗
Actions of cholera toxin and the prevention and treatment of cholera.
作者信息
Holmgren J
出版信息
Nature. 1981 Jul 30;292(5822):413-17. doi: 10.1038/292413a0.
DOI:10.1038/292413a0
PMID:7019725
Abstract
The drastic intestinal secretion of fluid and electrolytes that is characteristic of cholera is the result of reasonably well understood cellular and biochemical actions of the toxin secreted by Vibrio cholerae. Based on this understanding it is possible to devise new techniques for the treatment and prophylaxis of cholera to complement those based on fluid replacement therapy and sanitation.
摘要
霍乱的典型特征是肠道大量分泌液体和电解质，这是由霍乱弧菌分泌的毒素所产生的细胞和生化作用导致的，对此人们已有相当深入的了解。基于这一认识，有可能设计出治疗和预防霍乱的新技术，以补充基于补液疗法和环境卫生的方法。
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