无蛋白脂多糖对C3H/HeJ小鼠免疫反应的抑制作用。
Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides.
作者信息
Haas G P, Johnson A G, Nowotny A
出版信息
J Exp Med. 1978 Oct 1;148(4):1081-6. doi: 10.1084/jem.148.4.1081.
Abstract
The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experiments. This newly discovered effect of LPS in C3H/HeJ mice indicates that the adjuvant and inhibitory action of LPS may be distinct phenomena which are under different genetic regulation. Thus, the C3H/HeJ strain provides a convenient animal model for study of immunosuppression independent of the adjuvant effect.
摘要
本文所述实验表明，博伊文型脂多糖（LPS）和去蛋白化糖脂可抑制C3H/HeJ小鼠的噬斑形成细胞反应。体内和体外实验均观察到抑制作用，并且在共培养实验中该抑制作用可转移至正常细胞。LPS在C3H/HeJ小鼠中这一新发现的效应表明，LPS的佐剂作用和抑制作用可能是受不同基因调控的不同现象。因此，C3H/HeJ品系为研究独立于佐剂效应的免疫抑制提供了一个便利的动物模型。
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本文引用的文献
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Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
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J Exp Med. 1968 Jun 1;127(6):1087-107. doi: 10.1084/jem.127.6.1087.
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