大鼠耳软骨炎。用II型胶原诱导复发性多软骨炎的实验模型。
Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.
作者信息
Cremer M A, Pitcock J A, Stuart J M, Kang A H, Townes A S
出版信息
J Exp Med. 1981 Aug 1;154(2):535-40. doi: 10.1084/jem.154.2.535.
Abstract
Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen.
摘要
用天然II型胶原免疫远交系Wistar大鼠，会出现类似于人类复发性软骨炎的耳部病变。与人的疾病一样，这些病变的特征是严重的软骨炎、对IgG和C3的阳性免疫荧光反应，以及与天然II型胶原反应的循环IgG。此外，在软骨细胞表面附近可见电子致密沉积物，且与IgG和C3的沉积物相对应。这些观察结果表明，大鼠对II型胶原的体液免疫与耳软骨炎之间存在因果关系，并支持了人类复发性多软骨炎是一种由对II型胶原的免疫介导的自身免疫性疾病这一假说。
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