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制霉菌素抗性酵母突变体中中链脂肪酸比例增加。

Increased proportion of medium chain fatty acids in nystatin-resistant yeast mutants.

作者信息

Nagai J, Yokoe S, Tanaka M, Hibasami H, Ikeda T

出版信息

Lipids. 1981 Jun;16(6):411-7. doi: 10.1007/BF02535007.

DOI:10.1007/BF02535007
PMID:7022083
Abstract

Fatty acid composition of phospholipids and steryl esters from four nystatin-resistant mutants of Saccharomyces cerevisiae was compared to that from the wild strain. All the mutant strains which produce several ergosterol intermediates incorporated two- to three-fold as much medium chain fatty acids, especially 14:1 in phospholipids, and 12:0, 14:0 and 14:1 in steryl esters as the wild strain did. The increase in the relative amount of medium chain fatty acids in these mutants was found at all the growth temperatures and the growth phases examined, and in all the phospholipid species.

摘要

将酿酒酵母的四个制霉菌素抗性突变体的磷脂和甾醇酯的脂肪酸组成与野生菌株的进行了比较。所有产生几种麦角固醇中间体的突变菌株在磷脂中掺入的中链脂肪酸是野生菌株的两到三倍,尤其是14:1,在甾醇酯中掺入的12:0、14:0和14:1也是野生菌株的两到三倍。在所有检测的生长温度和生长阶段以及所有磷脂种类中,都发现这些突变体中链脂肪酸的相对含量增加。

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引用本文的文献

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Sterol methylation in Saccharomyces cerevisiae.酿酒酵母中的甾醇甲基化
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本文引用的文献

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Lipid composition of mesophilic and psychrophilic yeasts (Candida species) as influenced by environmental temperature.环境温度对嗜温及嗜冷酵母(假丝酵母属)脂质组成的影响
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METABOLISM OF STEAROLIC ACID IN YEAST.酵母中硬脂酸的代谢
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Biosythesis of branched chain fatty acids. I. Isolation and identification of fatty acids from Bacillus subtilis (ATCC 7059).支链脂肪酸的生物合成。I. 从枯草芽孢杆菌(ATCC 7059)中分离和鉴定脂肪酸。
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Substrate control of termination of fatty acid biosynthesis by fatty acid synthetase from Brevibacterium ammoniagenes.产氨短杆菌脂肪酸合成酶对脂肪酸生物合成终止的底物控制
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Effect of sterol side chains on growth and membrane fatty acid composition of Saccharomyces cerevisiae.甾醇侧链对酿酒酵母生长及膜脂肪酸组成的影响
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Nystatin-resistant mutants of yeast: alterations in sterol content.酵母的制霉菌素抗性突变体:固醇含量的改变
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The effect of ergosterol on the fatty acid composition of Tetrahymena pyriformis.麦角固醇对梨形四膜虫脂肪酸组成的影响。
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Biosynthesis of terpenes and steroids. IX. The sterols of some mutant yeasts and their relationship to the biosynthesis of ergosterol.萜类和甾体的生物合成。IX. 一些突变酵母的甾醇及其与麦角甾醇生物合成的关系。
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Sterol biosynthesis in antibiotic-resistant yeast: nystatin.抗抗生素酵母中的甾醇生物合成:制霉菌素。
Arch Biochem Biophys. 1974 Jan;160(1):83-9. doi: 10.1016/s0003-9861(74)80011-1.
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Isolation of pleiotropic yeast mutants requiring ergosterol for growth.分离生长需要麦角固醇的多效性酵母突变体。
Biochem Biophys Res Commun. 1973 Jun 8;52(3):741-7. doi: 10.1016/0006-291x(73)90999-6.