肝素中氨基糖苷活性的抑制作用。
Inhibition of aminoglycoside activity in heparin.
作者信息
Nilsson L, Maller R, Anséhn S
出版信息
Antimicrob Agents Chemother. 1981 Aug;20(2):155-8. doi: 10.1128/AAC.20.2.155.
Abstract
Measurements of aminoglycosides by an agar disk diffusion assay are inhibited by heparin in a dose-dependent way. When assayed by a homogeneous immunoassay, this was only evident for tobramycin. This indicates that specimens for aminoglycoside measurement should not be obtained in heparinized tubes. When heparin is used clinically as an anticoagulant, the amount in blood does not reach levels that affect the aminoglycoside activity.
摘要
通过琼脂扩散试验对氨基糖苷类进行测量时，肝素会以剂量依赖的方式抑制测量结果。当通过均相免疫测定法进行检测时，这种情况仅在妥布霉素检测中明显。这表明不应在肝素化试管中采集用于测量氨基糖苷类的标本。当肝素在临床上用作抗凝剂时，血液中的肝素量未达到影响氨基糖苷类活性的水平。
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Acta Med Scand. 1963 May;173:619-30. doi: 10.1111/j.0954-6820.1963.tb17446.x.
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