Reitamo S, Reunala T, Konttinen Y T, Saksela O, Salo O P
Br J Dermatol. 1981 Aug;105(2):167-77. doi: 10.1111/j.1365-2133.1981.tb01202.x.
Skin lesions were produced by application of 50% potassium iodide to twelve patients with dermatitis herpetiformis (DH). Perivascular cellular infiltrates were found to be characteristic of developing lesions. The cells were mainly round cells; alpha-naphthyl acetate esterase staining revealed that in 24-h lesions the mean percentage of T-lymphocytes was 43%, that of mononuclear phagocytes 6% and that of non-T/non-M cells (mainly B-lymphocytes) 44%. The percentage of the latter was highest (mean 81%) in 6-h specimens, suggesting that these cells are participating in the early stages of lesion formation. The infiltrating cells in dermal papillae and within subepidermal vesicles were predominantly polymorphonuclear leukocytes (mean 86%) with some mononuclear phagocytes and non-T/non-M cells. Immunofluorescence examination confirmed that fibrin deposition is characteristic of the initial lesions of DH and showed that the same is true of fibronectin. Seven out of eight patients had fibronectin deposits in dermal papillae. IgA was found in all and C3 in most of the specimens and, with the exception of papillary vesicles and blister cavities, the intensity of IgA and C3 fluorescence showed no marked alterations during the development of lesions.
对12例疱疹样皮炎（DH）患者应用50%碘化钾产生皮肤损害。发现血管周围细胞浸润是正在形成的损害的特征。这些细胞主要是圆形细胞；α-萘乙酸酯酶染色显示，在24小时的损害中，T淋巴细胞的平均百分比为43%，单核吞噬细胞为6%，非T/非M细胞（主要是B淋巴细胞）为44%。后者的百分比在6小时的标本中最高（平均81%），表明这些细胞参与了损害形成的早期阶段。真皮乳头和表皮下水疱内的浸润细胞主要是多形核白细胞（平均86%），还有一些单核吞噬细胞和非T/非M细胞。免疫荧光检查证实纤维蛋白沉积是DH初始损害的特征，并且显示纤连蛋白也是如此。8例患者中有7例在真皮乳头中有纤连蛋白沉积。在所有标本中均发现IgA，大多数标本中发现C3，并且除了乳头水疱和水疱腔外，在损害发展过程中IgA和C3荧光强度没有明显改变。
