Nuclear mutants of yeast with reduced spontaneous mutability of the mitochondrial genome.

Nuclear mutations in yeast were obtained that reduced rates of spontaneous mutations in the mitochondrial genome. The symbol mmg (mutability of mitochondrial genome) is used to designate these mutations. 2 types of mmg mutation are described: semidominant and recessive ones. Each of the 4 mutations studied is located in a separate mmg locus suggesting that there are probably more than 4 mmg loci in the nuclear genome of a yeast cell.