在加尔各答进行的磷酸铝吸附霍乱疫苗对照现场试验。
A controlled field trial of an aluminum phosphate-adsorbed cholera vaccine in Calcutta.
作者信息
Pal S C, Deb B C, Sen Gupta P G, De S P, Sircar B K, Sen D, Sikdar S N
出版信息
Bull World Health Organ. 1980;58(5):741-5.
A controlled field trial to determine the efficacy of a single dose of an aluminium phosphate-adsorbed cholera vaccine was conducted in Calcutta during 1975-77. An aluminium phosphate-adsorbed tetanus toxoid was used as the placebo. Follow-up of the immunized volunteers for a period of two years showed that the adsorbed cholera vaccine provided 100% protection to children under five years of age for 6 months, 88.9% for 12 months, and 91.7% for 18 months (P<0.05). The overall protection for all age groups was 58.5% for 18 months. There were no serious side effects following the anti-cholera inoculations.
1975年至1977年期间，在加尔各答进行了一项对照现场试验，以确定单剂量磷酸铝吸附霍乱疫苗的疗效。使用磷酸铝吸附破伤风类毒素作为安慰剂。对免疫志愿者进行了为期两年的随访，结果显示，吸附霍乱疫苗在6个月内为5岁以下儿童提供了100%的保护，12个月时为88.9%，18个月时为91.7%（P<0.05）。所有年龄组在18个月内的总体保护率为58.5%。接种抗霍乱疫苗后未出现严重副作用。
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