菲律宾霍乱及埃尔托霍乱疫苗有效性的对照现场试验。
A controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in the Philippines.
作者信息
Azurin J C, Cruz A, Pesigan T P, Alvero M, Camena T, Suplido R, Ledesma L, Gomez C Z
出版信息
Bull World Health Organ. 1967;37(5):703-27.
Abstract
A controlled field trial on some 584 000 people in an endemic cholera El Tor area in the Philippines demonstrated that cholera vaccines gave moderate protection of short duration. Injection of a single dose of vaccine prepared from either Vibrio cholerae or El Tor vibrios gave over 50% protection for the first 2 months. The immunity conferred by the V. cholerae vaccine declined rapidly after 3 to 4 months. The effectiveness of the El Tor vaccine continued for 6 months. An oil-adjuvant vaccine prepared from V. cholerae conferred an equally high degree of protection for a longer period of time, but, owing to severe vaccination reactions, its use could not be recommended.
摘要
在菲律宾霍乱埃尔托型流行地区对约58.4万人进行的一项对照现场试验表明，霍乱疫苗提供了持续时间较短的适度保护。注射一剂由霍乱弧菌或埃尔托弧菌制备的疫苗，在前两个月提供了超过50%的保护。霍乱弧菌疫苗赋予的免疫力在3至4个月后迅速下降。埃尔托疫苗的有效性持续了6个月。由霍乱弧菌制备的油佐剂疫苗在更长时间内提供了同样高程度的保护，但由于严重的疫苗接种反应，不建议使用。
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本文引用的文献
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Preparation and laboratory tests of oil-adjuvant cholera vaccine.油佐剂霍乱疫苗的制备及实验室检测
Bull World Health Organ. 1967;37(5):729-36.
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Bull World Health Organ. 1967;37(1):89-100.
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Preparation and potency testing of cholera and cholera El Tor vaccines.霍乱及埃尔托型霍乱疫苗的制备与效价检测
Bull World Health Organ. 1967;37(5):816-7.
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