Azurin J C, Cruz A, Pesigan T P, Alvero M, Camena T, Suplido R, Ledesma L, Gomez C Z
Bull World Health Organ. 1967;37(5):703-27.
A controlled field trial on some 584 000 people in an endemic cholera El Tor area in the Philippines demonstrated that cholera vaccines gave moderate protection of short duration. Injection of a single dose of vaccine prepared from either Vibrio cholerae or El Tor vibrios gave over 50% protection for the first 2 months. The immunity conferred by the V. cholerae vaccine declined rapidly after 3 to 4 months. The effectiveness of the El Tor vaccine continued for 6 months. An oil-adjuvant vaccine prepared from V. cholerae conferred an equally high degree of protection for a longer period of time, but, owing to severe vaccination reactions, its use could not be recommended.
在菲律宾霍乱埃尔托型流行地区对约58.4万人进行的一项对照现场试验表明,霍乱疫苗提供了持续时间较短的适度保护。注射一剂由霍乱弧菌或埃尔托弧菌制备的疫苗,在前两个月提供了超过50%的保护。霍乱弧菌疫苗赋予的免疫力在3至4个月后迅速下降。埃尔托疫苗的有效性持续了6个月。由霍乱弧菌制备的油佐剂疫苗在更长时间内提供了同样高程度的保护,但由于严重的疫苗接种反应,不建议使用。