Tateishi J, Koga M, Mori R
Acta Pathol Jpn. 1981 Nov;31(6):943-51. doi: 10.1111/j.1440-1827.1981.tb02008.x.
Tissues taken from 10 patients with Creutzfeldt-Jakob disease (CJD) were inoculated to many species of small rodents and primates. Successful transmission was done from 9 patients with a varied incidence after different incubation periods. After the second passage, the incidence became high and incubation periods were reduced approximately to four months in mice. Squirrel monkeys needed the longest incubation period in our experiments. Intracerebral inoculation was the fastest route of transmission followed by other parenteral and oral routes. Spongiform change and gliosis in the CNS were common pathological changes, though their distribution was peculiar to each animal species. The distribution in mice differed with each inoculated material taken from the patients, suggesting the multiplicity of CJD agents. Unconventional properties of the causative agent disclosed through this animal model were discussed.
从10例克雅氏病（CJD）患者身上获取的组织被接种到多种小型啮齿动物和灵长类动物身上。9例患者成功实现了传播，在不同的潜伏期后发病率各不相同。第二次传代后，发病率升高，小鼠的潜伏期缩短至约四个月。在我们的实验中，松鼠猴的潜伏期最长。脑内接种是最快的传播途径，其次是其他非肠道和口服途径。中枢神经系统中的海绵状变化和胶质细胞增生是常见的病理变化，尽管它们在每种动物物种中的分布都很独特。小鼠体内的分布因取自患者的每种接种材料而异，这表明CJD病原体具有多样性。通过该动物模型揭示的病原体非常规特性也进行了讨论。
