前列腺素在麻醉大鼠体内释放血浆“相互偶联因子”。
Prostaglandins release plasma 'reciprocal coupling factor' in anaesthetized rats.
作者信息
Hoult J R, Moore P K
出版信息
Br J Pharmacol. 1981 Oct;74(2):485-7. doi: 10.1111/j.1476-5381.1981.tb09994.x.
Abstract
- Prostaglandins E1, E2, I2 and endoperoxide analogue U46619 injected intra-arterially (i.a.) into anaesthetized rats at 2 micrograms/kg caused a substantial increase within 60 min of the plasma activity of prostaglandin 'reciprocal coupling factor' (RCF). RCF is the provisional name for the component(s) of plasma which inhibit microsomal prostaglandin synthesis and enhance cytosolic prostaglandin breakdown. 2. RCF is not released by inactive metabolite 13,14-dihydro-15-keto prostaglandin E2 (10 micrograms/kg, i.a.) or acetylcholine or histamine (2 micrograms/kg, i.a.). 3. We suggest that release by prostaglandins of RCF would provide the basis in vivo for a negative feedback mechanism controlling the activity of the prostaglandin system.
摘要
- 以2微克/千克的剂量将前列腺素E1、E2、I2和内过氧化物类似物U46619动脉内注射到麻醉大鼠体内，60分钟内血浆中前列腺素“相互偶联因子”（RCF）的活性显著增加。RCF是血浆中抑制微粒体前列腺素合成并增强胞质前列腺素分解的成分的暂定名称。2. 无活性代谢物13,14 - 二氢 - 15 - 酮前列腺素E2（10微克/千克，动脉内注射）、乙酰胆碱或组胺（2微克/千克，动脉内注射）不会释放RCF。3. 我们认为，前列腺素释放RCF将为体内控制前列腺素系统活性的负反馈机制提供基础。
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本文引用的文献
1
Human plasma contains prostaglandin 'reciprocal coupling factor'.人血浆中含有前列腺素“相互偶联因子”。
Eur J Pharmacol. 1980 Dec 19;68(4):509-11. doi: 10.1016/0014-2999(80)90429-x.
2
Pathophysiological states modify levels in rat plasma of factors which inhibit synthesis and enhance breakdown of PG.病理生理状态可改变大鼠血浆中抑制前列腺素合成并增强其分解的因子水平。
Nature. 1980 Nov 20;288(5788):271-3. doi: 10.1038/288271a0.
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Some biological effects of prostaglandin endoperoxide analogs.前列腺素内过氧化物类似物的一些生物学效应。
Life Sci. 1976 Jan 15;18(2):169-76. doi: 10.1016/0024-3205(76)90021-7.
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