Sánchez N P, Peters M S, Winkelmann R K
J Am Acad Dermatol. 1981 Dec;5(6):673-80. doi: 10.1016/s0190-9622(81)70129-4.
Lupus erythematosus panniculitis is a clinical variant of lupus erythematosus in which the main pathologic process involves the deep corium and subcutaneous tissue. We reviewed twenty-nine cases of lupus panniculitis, as well as the cases previously reported in the literature. The histopathologic changes in lupus panniculitis are characterized by a lymphocytic panniculitis, hyaline degeneration of the fat, hyaline papillary bodies, and lymphoid nodular structures in the lower dermis and subcutaneous tissue. Direct immunofluorescence can be important in supplementing the histopathologic study of lupus panniculitis. Lesions of discoid lupus erythematosus are seen in 21% of cases. When this disorder exists in the absence of other typical cutaneous or systemic lesions, the diagnosis of lupus erythematosus has been questioned. We believe that the histopathologic findings of this entity are alone sufficient for a diagnosis of lupus panniculitis, even in the absence of cutaneous or systemic lesions.
红斑狼疮性脂膜炎是红斑狼疮的一种临床变体，其主要病理过程累及真皮深层和皮下组织。我们回顾了29例狼疮性脂膜炎病例以及文献中先前报道的病例。狼疮性脂膜炎的组织病理学变化特征为淋巴细胞性脂膜炎、脂肪透明变性、透明乳头体以及真皮下部和皮下组织中的淋巴样结节结构。直接免疫荧光对补充狼疮性脂膜炎的组织病理学研究可能很重要。21%的病例可见盘状红斑狼疮病变。当这种疾病在没有其他典型皮肤或系统性病变的情况下存在时，红斑狼疮的诊断受到质疑。我们认为，即使没有皮肤或系统性病变，该实体的组织病理学发现单独就足以诊断狼疮性脂膜炎。
