Nieminen M M, Fyhrquist F, Linkola J, Tikkanen I, Tontti K
Pharmacol Biochem Behav. 1981 Dec;15(6):879-82. doi: 10.1016/0091-3057(81)90047-2.
The effect of acute moderate ethanol intoxication on renin-aldosterone axis was studied in four healthy humans in normal sodium and water balance. The subjects drank ethanol 1.2 g/kg body weight during 90 minutes. A dissociation between plasma renin activity (PRA) and plasma aldosterone took place; PRA increased (p less than 0.001) and aldosterone showed a decreasing trend, which was not significant. Serum Na+/K+-ratio increased (p less than 0.001). We observed no significant change in serum osmolality, blood pressure nor heart rate. The increase (p less than 0.001). We observed no significant change in serum osmolality, blood pressure nor heart rate. The increase in PRA was probably caused primarily by dehydration due to ethanol diuresis. The dissociation between plasma aldosterone and PRA may be associated with increasing serum Na+/K+-ratio or an inhibitory action of ethanol on aldosterone secretion.
在四名钠和水平衡正常的健康人体内，研究了急性中度乙醇中毒对肾素-醛固酮轴的影响。受试者在90分钟内饮用了1.2克/千克体重的乙醇。血浆肾素活性（PRA）和血浆醛固酮之间出现了分离；PRA升高（p<0.001），醛固酮呈下降趋势，但不显著。血清钠/钾比值升高（p<0.001）。我们观察到血清渗透压、血压和心率均无显著变化。PRA的升高可能主要是由乙醇利尿导致的脱水引起的。血浆醛固酮和PRA之间的分离可能与血清钠/钾比值升高或乙醇对醛固酮分泌的抑制作用有关。
