Vikhert A M, Volkov V N, Sokolova R I
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1986;9(1):45-8.
Plasma renin activity (PRA) and aldosterone concentration (PAC) were determined in early (up to 6 hours) autopsy material of 35 cases of sudden death (men aged 22-35). In half of cases alcohol was present in the blood. The same parameters were evaluated in 35 living men: 17 donors and 18 subjects with alcoholic intoxication. The presence of alcohol in the blood both in cases of sudden cardiac death (SCD) and in subjects with alcoholic intoxication was shown to result in a marked increase in PRA and PAC. Statistic analysis revealed a positive correlation between PRA and PAC in SCD in the presence of alcoholic intoxication, which is not observed when the latter is absent. These results suggest that aldosterone concentration in SCD may be increased due to some stimulating factors other than alcohol. Calcium balance disturbances could be one of them.
在35例猝死病例（年龄22 - 35岁男性）的早期（直至6小时）尸检材料中测定了血浆肾素活性（PRA）和醛固酮浓度（PAC）。半数病例血液中存在酒精。在35名活着的男性中评估了相同参数：17名献血者和18名酒精中毒受试者。结果显示，心源性猝死（SCD）病例和酒精中毒受试者血液中存在酒精均导致PRA和PAC显著升高。统计分析显示，存在酒精中毒时，SCD中PRA与PAC呈正相关，不存在酒精中毒时则未观察到这种相关性。这些结果表明，SCD中的醛固酮浓度可能因酒精以外的一些刺激因素而升高。钙平衡紊乱可能是其中之一。
