前列腺素E2对人体胃的细胞保护作用。

Gastric cytoprotection in man by prostaglandin E2.

作者信息

Ruppin H, Person B, Robert A, Domschke W

出版信息

Scand J Gastroenterol. 1981;16(5):647-52. doi: 10.3109/00365528109182025.

DOI:10.3109/00365528109182025

Abstract

In healthy volunteers, the effects of topical prostaglandins E2 (PGE2), 1 mg, on transmucosal potential difference (PD), mucus secretion, and epithelial cell turnover were investigated. PGE2 increased gastric PD by 10 mV on an average and stimulated mucus secretion of the stomach by 50%. In contrast, epithelial cell turnover remained unchanged. Gastric output of H+ decreased, whereas the outputs of volume, Na+, and Cl- rose in response to PGE2, which effects would be compatible with increased secretion of bicarbonate. Topical administration of ethanol 40% (vol/vol) reduced PD by 25 mV (delta PDE) and enhanced epithelial cell shedding by 350% with concomitant discharge of mucus from stomach epithelium. Pretreatment of the stomach with 1 mg PGE2 prevented the ethanol-dependent epithelial cell exfoliation, indicating gastric mucosal cytoprotection. Delta PDE and discharge of mucus were not significantly altered by PGE2. We conclude that gastric cytoprotection by PGE2 in man might be mediated by stimulation of mucus and/or bicarbonate production.

摘要

在健康志愿者中，研究了局部应用1毫克前列腺素E2（PGE2）对跨粘膜电位差（PD）、粘液分泌和上皮细胞更新的影响。PGE2平均使胃PD增加10毫伏，并使胃粘液分泌增加50%。相比之下，上皮细胞更新保持不变。H+的胃输出量减少，而体积、Na+和Cl-的输出量则因PGE2而增加，这些效应与碳酸氢盐分泌增加相符。局部应用40%（体积/体积）乙醇使PD降低25毫伏（δPDE），并使上皮细胞脱落增加350%，同时胃上皮有粘液排出。用1毫克PGE2预处理胃可防止乙醇依赖性上皮细胞剥脱，表明胃粘膜具有细胞保护作用。PGE2对δPDE和粘液排出无明显影响。我们得出结论，PGE2对人体胃的细胞保护作用可能是通过刺激粘液和/或碳酸氢盐的产生来介导的。