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1
Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients.“无反应性”肺结核患者淋巴组织中抗原特异性淋巴细胞滞留的初步证据。
Clin Exp Immunol. 1976 Oct;26(1):129-32.
2
The immunological consequences of antigen overload in experimental mycobacterial infections of mice.小鼠实验性分枝杆菌感染中抗原过载的免疫后果。
Clin Exp Immunol. 1975 Jan;19(1):167-77.
3
Sustained T-cell reactivity to Mycobacterium tuberculosis specific antigens in 'split-anergic' leprosy.“分裂无反应性”麻风病中对结核分枝杆菌特异性抗原的持续性T细胞反应性
Lepr Rev. 1995 Mar;66(1):19-25.
4
Suppressed induction of mycobacterial antigen-specific Th1-type CD4+ T cells in the lung after pulmonary mycobacterial infection.肺部分枝杆菌感染后，肺部分枝杆菌抗原特异性 Th1 型 CD4+ T 细胞的诱导受到抑制。
Int Immunol. 2010 Apr;22(4):307-18. doi: 10.1093/intimm/dxq010. Epub 2010 Feb 18.
5
The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.在被分枝杆菌产物“过载”的小鼠淋巴结中，巨噬细胞对淋巴细胞的体外增强、促有丝分裂和抑制作用。
Clin Exp Immunol. 1975 Jul;21(1):163-72.
6
Longitudinal analysis of Mycobacterium tuberculosis 19-kDa antigen-specific T cells in patients with pulmonary tuberculosis: association with disease activity and cross-reactivity to a peptide from HIVenv gp120.肺结核患者中结核分枝杆菌19-kDa抗原特异性T细胞的纵向分析：与疾病活动的关联以及对HIV env gp120肽段的交叉反应性
Eur J Immunol. 2003 Jun;33(6):1613-23. doi: 10.1002/eji.200323480.
7
Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa.对结核分枝杆菌抗原获得性免疫反应的遗传调控：西非双胞胎研究
Infect Immun. 2001 Jun;69(6):3989-94. doi: 10.1128/IAI.69.6.3989-3994.2001.
8
[Phenotypic and functional analysis of blood lymphocytes and pathological focus in patients with pulmonary tuberculosis].肺结核患者血液淋巴细胞及病理病灶的表型与功能分析
Probl Tuberk. 1995(2):42-3.
9
The effect of delayed addition of antigen and 'E' rosetting on the proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal individuals or from patients with tuberculosis or leprosy.延迟添加抗原和“E”花环形成对正常个体、结核病患者或麻风病患者外周血淋巴细胞对分枝杆菌抗原增殖反应的影响。
Immunology. 1981 Nov;44(3):585-91.
10
Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection.抗原负荷决定了CD8 T细胞对卡介苗或结核分枝杆菌感染的不同启动反应。
J Immunol. 2009 Jun 1;182(11):7172-7. doi: 10.4049/jimmunol.0801694.

引用本文的文献

1
Immunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculosis infection and disease.结核分枝杆菌感染与疾病中外周血T淋巴细胞的免疫表型特征
Clin Exp Immunol. 2002 Apr;128(1):149-54. doi: 10.1046/j.1365-2249.2002.01809.x.
2
Antigen specificity in experimental bovine tuberculosis.实验性牛结核病中的抗原特异性
Infect Immun. 2000 May;68(5):2573-8. doi: 10.1128/IAI.68.5.2573-2578.2000.
3
Bovine tuberculosis: immune responses in the peripheral blood and at the site of active disease.牛结核病：外周血及活动性疾病部位的免疫反应
Immunology. 2000 Feb;99(2):195-202. doi: 10.1046/j.1365-2567.2000.00944.x.
4
Protein deficiency induces alterations in the distribution of T-cell subsets in experimental pulmonary tuberculosis.蛋白质缺乏会导致实验性肺结核中T细胞亚群分布的改变。
Infect Immun. 1998 Mar;66(3):927-31. doi: 10.1128/IAI.66.3.927-931.1998.
5
Fatal pulmonary infection with Mycobacterium celatum in an apparently immunocompetent patient.一名看似免疫功能正常的患者发生了由塞拉分枝杆菌引起的致命肺部感染。
J Clin Microbiol. 1998 Feb;36(2):587-8. doi: 10.1128/JCM.36.2.587-588.1998.
6
Cellular and humoral immune responses to recombinant 65-kD antigen of Mycobacterium leprae in leprosy patients and healthy controls.麻风病患者和健康对照对麻风分枝杆菌重组65-kD抗原的细胞免疫和体液免疫反应。
Clin Exp Immunol. 1994 Apr;96(1):79-85. doi: 10.1111/j.1365-2249.1994.tb06234.x.
7
Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls.结核病患者与健康对照者的免疫反应性及淋巴因子产生
Infect Immun. 1994 Dec;62(12):5673-8. doi: 10.1128/iai.62.12.5673-5678.1994.
8
Mycobacteria and the skin.分枝杆菌与皮肤。
Int J Dermatol. 1982 Nov;21(9):497-503. doi: 10.1111/j.1365-4362.1982.tb01190.x.
9
Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy.前列腺素依赖性调节正常供体以及结核病或麻风病患者外周血淋巴细胞对分枝杆菌抗原的体外增殖反应。
Clin Exp Immunol. 1981 Sep;45(3):646-53.
10
Kinetics of peripheral blood leukocyte alterations in Thai children with dengue hemorrhagic fever.泰国登革出血热儿童外周血白细胞变化的动力学
Infect Immun. 1980 May;28(2):428-33. doi: 10.1128/iai.28.2.428-433.1980.

本文引用的文献

1
The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs.脱敏豚鼠中抗原反应性淋巴细胞的区室化
J Exp Med. 1971 Sep 1;134(3 Pt 1):741-50. doi: 10.1084/jem.134.3.741.
2
A preliminary report on some studies of environmental mycobacteria.关于环境分枝杆菌一些研究的初步报告。
Ann Soc Belg Med Trop. 1973;53(4):389-93.
3
Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy.在麻风病的整个临床和组织病理学范围内，对麻风分枝杆菌及其他分枝杆菌抗原的免疫反应性。
Clin Exp Immunol. 1973 Aug;14(4):541-53.
4
Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats.F1杂种大鼠循环淋巴细胞在接触组织相容性抗原后出现的特异性无反应性。
Nat New Biol. 1971 Dec 8;234(49):178-80. doi: 10.1038/newbio234178a0.
5
Antigen-induced selective recruitment of circulating lymphocytes.抗原诱导的循环淋巴细胞选择性募集。
Cell Immunol. 1971 Apr;2(2):171-81. doi: 10.1016/0008-8749(71)90036-0.
6
Restoration of specific immunological virginity.特定免疫原初状态的恢复。
Nature. 1974 Jul 12;250(462):113-6. doi: 10.1038/250113a0.
7
The specific selection of recirculating lymphocytes by antigen in normal and preimmunized rats.正常和预先免疫大鼠中抗原对循环淋巴细胞的特异性选择。
J Exp Med. 1972 Sep 1;136(3):499-513. doi: 10.1084/jem.136.3.499.
8
The immunological consequences of antigen overload in experimental mycobacterial infections of mice.小鼠实验性分枝杆菌感染中抗原过载的免疫后果。
Clin Exp Immunol. 1975 Jan;19(1):167-77.
9
The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.在被分枝杆菌产物“过载”的小鼠淋巴结中，巨噬细胞对淋巴细胞的体外增强、促有丝分裂和抑制作用。
Clin Exp Immunol. 1975 Jul;21(1):163-72.
10
Multiple skin testing of Kenyan schoolchildren with a series of new tuberculins.对肯尼亚学童进行一系列新型结核菌素的多次皮肤测试。
J Hyg (Lond). 1975 Oct;75(2):303-13. doi: 10.1017/s002217240004732x.

“无反应性”肺结核患者淋巴组织中抗原特异性淋巴细胞滞留的初步证据。

Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients.

作者信息

Rook G A, Carswell J W, Stanford J L

出版信息

Clin Exp Immunol. 1976 Oct;26(1):129-32.

PMID:826362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540826/
Abstract

Lymphocyte-transformation responses to mycobacterial antigens have been studied, using paired blood and lymph node samples from 'normal' Ugandans, (hernia repairs or orthopaedic cases) or from patients with tuberculosis, Mycobacterium ulcerans infection, or injection abscesses. The results suggest that in some individuals, antigen reactive cells, although absent from the periphery, may be demonstrable in the lymph nodes. This phenomenon is most striking in skin-test negative tuberculosis patients.

摘要

已利用来自“正常”乌干达人（疝气修补或骨科病例）、结核病患者、溃疡分枝杆菌感染患者或注射脓肿患者的配对血液和淋巴结样本，研究了对分枝杆菌抗原的淋巴细胞转化反应。结果表明，在一些个体中，抗原反应性细胞虽然在外周血中不存在，但在淋巴结中可能可以检测到。这种现象在皮肤试验阴性的结核病患者中最为明显。