Bulovskaya L N, Krupkin R G, Bochina T A, Shipkova A A, Pavlova M V
Oncology. 1978;35(4):185-8. doi: 10.1159/000225282.
Acetylator phenotype was established by the method of Evans in 41 patients with breast cancer and 38 female controls. The results showed that the group of patients with advanced breast cancer included relatively more "rapid" --acetylating females (68% of "rapid and 32% of "slow" acetylators) as compared with controls (37% of "rapid" and 63% of "slow" acetylators). Moreover, the level of acetylating in both "rapid" and "slow" acetylating breast cancer patients were found to be higher than in corresponding groups of controls. A possible association between changes in the activity of acetylation in breast cancer patients and the genetic regulation processes in tumor growth is discussed.
采用埃文斯方法在41例乳腺癌患者和38名女性对照者中确定乙酰化表型。结果显示，与对照组（“快速”乙酰化者占37%，“慢速”乙酰化者占63%）相比，晚期乳腺癌患者组中“快速”乙酰化女性相对较多（“快速”乙酰化者占68%，“慢速”乙酰化者占32%）。此外，发现“快速”和“慢速”乙酰化乳腺癌患者的乙酰化水平均高于相应对照组。文中讨论了乳腺癌患者乙酰化活性变化与肿瘤生长中的基因调控过程之间可能存在的关联。
