Manzo C, Longo C, Bianchin A
Tumori. 1982 Feb 28;68(1):47-52. doi: 10.1177/030089168206800108.
Circulating immune complexes (CIC) were detected and quantitated in human breast cancer to monitor the efficiency of mastectomy. For this aim a microimmunoenzymatic test was set up, applying a solid-phase C1q. Features of this assay can be summarized as follows: ability to estimate as low as 10 ng of aggregated human IgG (delta IgG), good reproducibility and simplicity of execution, and small serum sample required. A group of women with breast cancer at different stages (TNM classification) was tested for CIC, and 31.75% were positive. Almost all patients submitted to surgery showed a reduction of this parameter thereafter. A parallel study was carried out in another group of women with benign breast disease, and a significant incidence of CIC was found.
在人类乳腺癌中检测并定量循环免疫复合物（CIC），以监测乳房切除术的效果。为此目的，建立了一种微免疫酶试验，应用固相C1q。该检测方法的特点可总结如下：能够检测低至10 ng的聚合人IgG（δIgG），具有良好的重复性和操作简便性，并且所需血清样本量小。对一组处于不同阶段（TNM分类）的乳腺癌女性进行了CIC检测，其中31.75%呈阳性。几乎所有接受手术的患者此后该参数都有所降低。在另一组患有良性乳腺疾病的女性中进行了平行研究，发现CIC的发生率很高。
