Patel G V, Gopal R, Nadkarni J J
Cancer Immunol Immunother. 1985;20(1):80-4. doi: 10.1007/BF00199778.
Circulating immune complexes (CICs) have been detected in the sera of patients with non-Hodgkin's lymphoma (NHL), Hodgkin's disease, chronic myeloid leukemia, and acute lymphoblastic leukemia by using C1q-binding and L1210-binding assays. Both assays gave broadly similar patterns of reactivity in terms of frequency and magnitude, though there are some differences. Significantly elevated CIC levels were observed in all pathologic groups. However, sera from NHL patients with an unfavorable prognosis consistently exhibited the highest frequency of positive values and mean CIC levels in both these assays. The two tests showed concordance in 66.6% of the NHL patients' sera and were significantly correlated. Of the sera from NHL patients 12.7% were positive in the C1q-binding assay only and 15.9% in the L1210-binding assay only. Both the assays gave positive results in some patients, and a degree of overlap indicates the presence of different types of CIC in cancer patients' sera. The combined use of two methods for detecting CICs may be useful for evaluation of the activity, the extent, and the prognosis of the malignant disease.
通过使用C1q结合试验和L1210结合试验，在非霍奇金淋巴瘤（NHL）、霍奇金病、慢性粒细胞白血病和急性淋巴细胞白血病患者的血清中检测到循环免疫复合物（CIC）。尽管存在一些差异，但两种试验在反应频率和强度方面给出了大致相似的反应模式。在所有病理组中均观察到CIC水平显著升高。然而，预后不良的NHL患者血清在这两种试验中始终呈现出最高的阳性值频率和平均CIC水平。这两项检测在66.6%的NHL患者血清中显示出一致性，且具有显著相关性。在NHL患者的血清中，12.7%仅在C1q结合试验中呈阳性，15.9%仅在L1210结合试验中呈阳性。两种试验在一些患者中均给出了阳性结果，一定程度的重叠表明癌症患者血清中存在不同类型的CIC。联合使用两种检测CIC的方法可能有助于评估恶性疾病的活性、范围和预后。
