Suitters A J, Lampert I A
Br J Exp Pathol. 1982 Apr;63(2):207-13.
Ia antigen is seen in the normal epidermis only in Langerhans cells. However, when there is damage to the epidermis induced by cellular immunity Ia is expressed in the keratinocytes. This phenomenon is not seen in trauma or chemical inflammation. It is suggested that the expression of Ia in keratinocytes is due to cellular immunity possibly due to a lymphokine.
Ia抗原仅在正常表皮的朗格汉斯细胞中可见。然而,当细胞免疫诱导表皮损伤时,角质形成细胞中会表达Ia。这种现象在创伤或化学性炎症中未见。提示角质形成细胞中Ia的表达可能归因于细胞免疫,可能是由于一种淋巴因子。