McNabb M E, Ebert R V, McCusker K
JAMA. 1982 Aug 20;248(7):865-8.
Nicotine chewing gum is designed to maintain plasma nicotine levels during a smoking cessation effort while the individual copes with the loss of the repetitive behavioral components of smoking. The plasma nicotine levels obtained with hourly gum chewing were compared with levels obtained with cigarette smoking in nine patients with lung disease. Chewing 2- and 4-mg nicotine gum hourly produced mean steady-state plasma nicotine levels of 11.8 and 23.2 ng/mL, respectively. This compares with a mean plasma nicotine trough level during usual smoking of 15.7 ng/mL and a mean trough level of 18.3 ng/mL with hourly smoking of a cigarette with a nicotine yield of 1.1 mg. Few side effects were seen with the use of either the 2- or 4-mg gum. In a short-term study, nicotine gum proved an acceptable source of nicotine for aiding smoking cessation.
尼古丁咀嚼胶旨在帮助戒烟者在戒烟过程中维持血浆尼古丁水平，同时应对吸烟时重复行为的缺失。研究人员比较了9名肺病患者每小时咀嚼口香糖所获得的血浆尼古丁水平与吸烟时的血浆尼古丁水平。每小时咀嚼2毫克和4毫克尼古丁口香糖分别产生的平均稳态血浆尼古丁水平为11.8纳克/毫升和23.2纳克/毫升。相比之下，通常吸烟时的平均血浆尼古丁谷值水平为15.7纳克/毫升，每小时吸一支尼古丁含量为1.1毫克的香烟时的平均谷值水平为18.3纳克/毫升。使用2毫克或4毫克口香糖时几乎没有副作用。在一项短期研究中，尼古丁口香糖被证明是一种有助于戒烟的可接受的尼古丁来源。
