Rest J R
Trans R Soc Trop Med Hyg. 1982;76(3):410-5. doi: 10.1016/0035-9203(82)90203-6.
Plasmodium berghei ANKA was tested for its usefulness as a model for cerebral malaria in inbred mouse strains A, A2G, A/J, C57L, SJL/J and SWR. A suitable model was obtained in A or A/J strain mice. Mortality was 100% after five to eight days with brain haemorrhages occurring terminally. The histopathology is described. The model was stable after six blood passages at 5- to 7-day intervals. Chloroquine abolished the haemorrhages and no intercurrent viral or blood protozoal infections were detected.
对伯氏疟原虫ANKA株在近交系小鼠品系A、A2G、A/J、C57L、SJL/J和SWR中作为脑型疟疾模型的适用性进行了测试。在A或A/J品系小鼠中获得了合适的模型。5至8天后死亡率为100%，末期出现脑出血。描述了组织病理学情况。该模型在每隔5至7天进行6次血液传代后保持稳定。氯喹消除了出血现象，且未检测到并发的病毒或血液原虫感染。
