Watson P J, McQuay H J, Bullingham R E, Allen M C, Moore R A
Br J Anaesth. 1982 Jan;54(1):37-43. doi: 10.1093/bja/54.1.37.
The plasma concentrations and clinical effects of a single i.v. dose of buprenorphine 0.3 or 0.6 mg were studied in patients recovering from surgery. Analgesic and hormonal effects were greater with the greater dose without a parallel increase in respiratory depression. A comparison with previous work suggests that increased efficacy results either from the use of the larger dose or equivalently if the first required postoperative dose of 0.3 mg has been preceded by a similar loading dose.
对手术恢复患者单次静脉注射0.3毫克或0.6毫克丁丙诺啡后的血浆浓度及临床效果进行了研究。较大剂量的镇痛和激素效应更强，但呼吸抑制并未相应增加。与先前研究相比表明，疗效提高要么是因为使用了较大剂量，要么是因为在首次术后所需的0.3毫克剂量之前先给予了类似的负荷剂量，效果相当。
