McQuay H J, Bullingham R E, Paterson G M, Moore R A
Br J Anaesth. 1980 Oct;52(10):1013-9. doi: 10.1093/bja/52.10.1013.
The analgesic, respiratory and hormonal effects of two doses of buprenorphine were studied during and after operation in 20 patients undergoing total hip replacement. The drug provided analgesia of long duration. The analesic and hormonal effects of the drug were greater after i.m. than after i.v. administration. The postoperative analgesic requirement of women was less than that of men. The pharmacodynamic differences shown between the sexes and between the two routes of administration are discussed in relation to the pharmacokinetics of the drug.
在20例接受全髋关节置换术的患者手术期间及术后，研究了两种剂量丁丙诺啡的镇痛、呼吸及激素效应。该药物可提供长时间的镇痛作用。肌肉注射给药后该药物的镇痛及激素效应比静脉注射给药后更强。女性术后的镇痛需求低于男性。结合该药物的药代动力学对两性之间以及两种给药途径之间显示出的药效学差异进行了讨论。
