Goldmeier D, Johnson A
Br J Vener Dis. 1982 Feb;58(1):40-3. doi: 10.1136/sti.58.1.40.
The progress of 58 patients with first attacks of genital herpes was monitored for up to 30 weeks. The effects of sex (gender), age, social class, and non-psychotic psychiatric illness (as measured by the "general health questionnaire," GHQ) on the recurrence rate of herpes was studied. The recurrence rates, measured by the actuarial percentage recurrence-free curves, showed that the 29 patients with GHQ scores above 11 had a significantly higher recurrence rate than those who scored less than 11 (P = 0.002). There were no important differences between recurrence rates according according to sex, age, or social class. These findings suggest that non-psychotic states, such as anxiety or obsessionality resulting in GHQ scores above 12, may possibly cause an excess production of adrenergic substances which encourages reactivation of latent genital herpes. Thus, to lessen the recurrence rate in such patients, a psychological or chemical approach to treatment could be used to modify the autonomic sympathetic response.
对58例初发性生殖器疱疹患者进行了长达30周的病情监测。研究了性别、年龄、社会阶层以及非精神病性精神疾病（通过“一般健康问卷”，即GHQ进行测量）对疱疹复发率的影响。通过精算无复发百分比曲线测量的复发率表明，GHQ评分高于11分的29例患者的复发率显著高于评分低于11分的患者（P = 0.002）。根据性别、年龄或社会阶层划分的复发率之间没有重要差异。这些发现表明，诸如焦虑或强迫观念等导致GHQ评分高于12分的非精神病状态，可能会导致肾上腺素能物质过度产生，从而促使潜伏的生殖器疱疹重新激活。因此，为了降低此类患者的复发率，可以采用心理或化学治疗方法来改变自主交感神经反应。
