van Nieuwkoop J A, Brand A, Radl J, Skvaril F
Int Arch Allergy Appl Immunol. 1982;67(1):61-5. doi: 10.1159/000232989.
5 sera from a series of more than 1,000 serum samples from hospitalized patients tested by immunoelectrophoresis were selected for further examination because of a disproportional increase in the anodic part of IgG. A marked polyclonal increase in IgG4 subclass level was detected in each of these sera. While the patients suffered from a variety of diseases (e.g. Loeffler's syndrome, leiomyosarcoma, periarteritis nodosa, chronic bronchitis, and mycosis fungoides, respectively), they all had an acquired respiratory disease as the only common clinical denominator.
在对1000多份住院患者血清样本进行免疫电泳检测时，由于IgG阳极部分不成比例增加，从这些样本中选取了5份血清作进一步检测。在每份血清中均检测到IgG4亚类水平显著的多克隆增加。虽然这些患者分别患有多种疾病（如吕弗勒综合征、平滑肌肉瘤、结节性多动脉炎、慢性支气管炎和蕈样肉芽肿），但他们都有一种后天性呼吸道疾病，这是唯一的共同临床特征。
