全血和血浆储存过程中邻苯二甲酸单-2-乙基己酯（MEHP）的积累。

The accumulation of mono-2-ethylhexylphthalate (MEHP) during storage of whole blood and plasma.

作者信息

Rock G, Secours V E, Franklin C A, Chu I, Villeneuve D C

出版信息

Transfusion. 1978 Sep-Oct;18(5):553-8. doi: 10.1046/j.1537-2995.1978.18579036383.x.

DOI:10.1046/j.1537-2995.1978.18579036383.x

Abstract

The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable concern for some time. We have followed the accumulation of DEHP and one of its major metabolities, mono-2-ethylhexylphthalate (MEHP) during storage of whole blood, platelet-rich plasma, platelet concentrates, and platelet-poor plasma for periods ranging from 72 hours to four weeks. Both phthalates showed a progressive increase in concentration with time. While the levels of DEHP were much greater than those of MEHP, there was nonetheless a significant and continual increase in MEHP in all preparations. The highest concentrations of both DEHP and MEHP were found in the platelet-poor plasma, indicating that platelets do not have a major role in the accumulation of the phthalates in blood. The accumulation of MEHP was shown to be a direct result of the metabolism of DEHP by plasma protein(s) rather than leaching from the blood bag.

摘要

一段时间以来，血液及血液成分中增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）的蓄积一直备受关注。我们追踪了全血、富血小板血浆、血小板浓缩物及少血小板血浆在72小时至四周的储存期内DEHP及其主要代谢产物之一邻苯二甲酸单（2-乙基己基）酯（MEHP）的蓄积情况。两种邻苯二甲酸酯的浓度均随时间逐渐升高。虽然DEHP的水平远高于MEHP，但在所有制剂中MEHP仍显著且持续增加。DEHP和MEHP的最高浓度均出现在少血小板血浆中，这表明血小板在血液中邻苯二甲酸酯的蓄积过程中并非主要作用因素。MEHP的蓄积被证明是血浆蛋白对DEHP代谢的直接结果，而非来自血袋的溶出。