Gerber G B, Maes J, Eykens B
Arch Toxicol. 1982 Jan;49(2):159-68. doi: 10.1007/BF00332363.
The transfer of 73As and 125SB to the developing mouse organism was studied in the following ways. a)A diet containing the isotopes was given from the day of the vaginal plug and the radioactivity in uterus, ovaries and different maternal organs was determined 2,4, and 6 days after initiation of feeding. b)The isotopes were injected i.p. during organogenesis at day 12, and the transfer into the fetus as well as activity in maternal organs were followed for a period of 7 days. c)The radioactive diet was supplied during the entire pregnancy and 15 days thereafter. The radioactivity in the females was followed for 150 days, that in the litter for 50 days. Components of turnover of less than a day, less than a week and several months can be discerned in the adult for both isotopes and transfer to the fetus occurs during organogenesis. Less antimony than arsenic is transferred from food during fetal life. After birth, arsenic as well as antimony are taken up by the newborn via the milk.
通过以下方式研究了73As和125Sb向发育中的小鼠机体的转移情况。a）从发现阴道栓之日起给予含同位素的饮食，并在开始喂食后的第2、4和6天测定子宫、卵巢和不同母体器官中的放射性。b）在器官发生期的第12天腹腔注射同位素，并追踪其向胎儿的转移以及母体器官中的活性，为期7天。c）在整个孕期及之后的15天提供放射性饮食。对雌性动物的放射性追踪150天，对幼崽的追踪50天。对于这两种同位素，在成年动物中可以辨别出周转时间少于一天、少于一周和数月的成分，并且在器官发生期会发生向胎儿的转移。在胎儿期，从食物中转移的锑比砷少。出生后，新生儿通过乳汁摄取砷和锑。
