Satinoff E, Liran J, Clapman R
Am J Physiol. 1982 Mar;242(3):R352-7. doi: 10.1152/ajpregu.1982.242.3.R352.
The normal amplitude of the circadian rhythm of telemetered body temperature (Tb) in male rats was 2 degrees C (between 36 and 38 degrees C). For several weeks after large medial preoptic lesions Tb cycled from as low as 29 degrees C to as high as 41 degrees C in a single day. With recovery, or in rats with smaller lesions, peak-to-trough Tb amplitudes decreased, ranging between 3 and 5 degrees C for many months, with normal or slightly raised troughs in the light part and grossly higher peaks in the dark part of a 12:12 light-dark cycle. Rats in whom some periventricular tissue was spared had normal amplitudes of Tb, but the whole curve was displaced 0.5-1.0 degrees C above control values. These effects persisted in constant darkness. We conclude that in the weeks after medial preoptic lesions thermoregulatory responses are not activated until Tb is abnormally high or low. As recovery progresses, or if the lesions are smaller to begin with, there may be an imbalance between heat loss and heat production systems so that heat production mechanisms are either always dominant or overshoot when activated.
雄性大鼠遥测体温（Tb）的昼夜节律正常幅度为2摄氏度（在36至38摄氏度之间）。在内侧视前区大面积损伤后的几周内，Tb在一天内从低至29摄氏度循环至高达41摄氏度。随着恢复，或者在损伤较小的大鼠中，Tb的峰谷幅度减小，在许多个月内介于3至5摄氏度之间，在12:12明暗循环的光照期低谷正常或略有升高，而在黑暗期峰值则明显更高。部分室周组织未受损的大鼠Tb幅度正常，但整个曲线比对照值高出0.5 - 1.0摄氏度。这些效应在持续黑暗中持续存在。我们得出结论，在内侧视前区损伤后的几周内，直到Tb异常高或低时，体温调节反应才会被激活。随着恢复的进展，或者如果损伤一开始较小，散热和产热系统之间可能会出现失衡，以至于产热机制要么始终占主导地位，要么在被激活时会过度反应。
